职称：

教授

研究方向：

主要研究领域为肺动脉高压的发生、发展的细胞分子机制；信号转导在心血管疾病以及右心衰竭发生发展中的调控作用；肺动脉高压药物治疗及新靶点的研究。

科研项目：

1、国家自然科学基金重点项目，81630004，p53信号通路调控异常在肺动脉高压发病中的机制研究，2017/01-2021/12，270万，在研，参与

2、国家自然科学基金面上项目，81770059，PHD2/VHL/HIF2a在肺动脉展中的作用及机制研究，2018/1-2021/12，58万，在研，主持

3、广州医科大学 “南山学者”高层次人才引进项目，肺血管疾病的发生发展研究，2018/1-2023/1，500万，在研，主持

4、呼吸疾病国家重点实验室开放课题，Salusin-β调控肺动脉高压肺血管内皮功能和血管重构的作用研究，2019/01-2021/12，20万，在研，主持

代表性学术论文：

1、Zhu Z, Godana D, Li A, Rodriguez B, Tang H, Minshall R, Huang W, Chen J. EXPRESS: Echocardiographic Assessment of Right Ventricular Functions in Experimental Pulmonary Hypertension. Pulm Circ. 2019 Apr 3:2045894019841987.

2、Zhang F#, Tang H#, Sun S, Luo Y, Ren X, Chen A, Xu Y, Li P, Han Y. Angiotensin-(1-7) induced vascular relaxation in spontaneously hypertensive rats. Nitric Oxide. 2019 Mar 14;88:1-9.

3、Wang Z#, Yang K#, Zheng Q#, Zhang C#, Tang H#, Babicheva A, Jiang Q, Li M, Chen Y, Carr SG, Wu K, Zhang Q, Balistrieri A, Wang C, Song S, Ayon RJ, Desai AA, Black SM, Garcia JGN, Makino A, Yuan JX, Lu W, Wang J*. Divergent changes of p53 in pulmonary arterial endothelial and smooth muscle cells involved in the development of pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2019 Jan 1;316(1):L216-L228.

4、Tang H#, Wu K#, Wang J#, Vinjamuri S, Gu Y, Song S, Wang Z, Zhang Q, Balistrieri A, Ayon RJ, Rischard F, Vanderpool R, Chen J, Zhou G, Desai AA, Black SM, Garcia JGN, Yuan JX, Makino A*. Pathogenic Role of mTORC1 and mTORC2 in Pulmonary Hypertension. JACC Basic Transl Sci. 2018 Dec 31;3(6):744-762.

5、Rhodes CJ, Batai K, Bleda M, Haimel M, Southgate L, Germain M, Pauciulo MW, Hadinnapola C, Aman J, Girerd B, Arora A, Knight J, Hanscombe KB, Karnes JH, Kaakinen M, Gall H, Ulrich A, Harbaum L, Cebola I, Ferrer J, Lutz K, Swietlik EM, Ahmad F, Amouyel P, Archer SL, Argula R, Austin ED, Badesch D, Bakshi S, Barnett C, Benza R, Bhatt N, Bogaard HJ, Burger CD, Chakinala M, Church C, Coghlan JG, Condliffe R, Corris PA, Danesino C, Debette S, Elliott CG, Elwing J, Eyries M, Fortin T, Franke A, Frantz RP, Frost A, Garcia JGN, Ghio S, Ghofrani HA, Gibbs JSR, Harley J, He H, Hill NS, Hirsch R, Houweling AC, Howard LS, Ivy D, Kiely DG, Klinger J, Kovacs G, Lahm T, Laudes M, Machado RD, Ross RVM, Marsolo K, Martin LJ, Moledina S, Montani D, Nathan SD, Newnham M, Olschewski A, Olschewski H, Oudiz RJ, Ouwehand WH, Peacock AJ, Pepke-Zaba J, Rehman Z, Robbins I, Roden DM, Rosenzweig EB, Saydain G, Scelsi L, Schilz R, Seeger W, Shaffer CM, Simms RW, Simon M, Sitbon O, Suntharalingam J, Tang H, Tchourbanov AY, Thenappan T, Torres F, Toshner MR, Treacy CM, VonkNoordegraaf A, Waisfisz Q, Walsworth AK, Walter RE, Wharton J, White RJ, Wilt J, Wort SJ, Yung D, Lawrie A, Humbert M, Soubrier F, Trégouët DA, Prokopenko I, Kittles R, Gräf S, Nichols WC, Trembath RC, Desai AA, Morrell NW, Wilkins MR. Genetic determinants of risk in pulmonary arterial hypertension: international genome-wide association studies and meta-analysis. Lancet Respir Med. 2018 Dec 5. pii: S2213-2600(18)30409-0.

6、Shu J, Lu W, Yang K, Zheng Q, Li D, Li Y, Kuang M, Liu H, Li Z, Chen Y, Zhang C, Luo X, Huang J, Wu X, Tang H, Wang J. Establishment and evaluation of chronic obstructive pulmonary disease model by chronic exposure to motor vehicle exhaust combined with lipopolysaccharide instillation. Exp Physiol. 2018 Nov;103(11):1532-1542.

7、Dai J, Zhou Q, Tang H, Chen T, Li J, Raychaudhuri P, Yuan JX, Zhou G. Smooth muscle cell-specific FoxM1 controls hypoxia-induced pulmonary hypertension. Cell Signal. 2018 Nov;51:119-129.

8、Tang H#, Babicheva A#, McDermott KM, Gu Y, Ayon RJ, Song S, Wang Z, Gupta A, Zhou T, Sun X, Dash S, Wang Z, Balistrieri A, Zheng Q, Cordery AG, Desai AA, Rischard F, Khalpey Z, Wang J, Black SM, Garcia JGN, Makino A, Yuan JX*. Endothelial HIF-2α contributes to severe pulmonary hypertension due to endothelial-to-mesenchymal transition. Am J Physiol Lung Cell Mol Physiol. 2018 Feb 1;314(2):L256-L275.

9、Qian Z, Liu H, Li M, Shi J, Li N, Zhang Y, Zhang X, Lv J, Xie X, Bai Y, Ge Q, Ko EA, Tang H, Wang T, Wang X, Wang Z, Zhou T, Gu W. Potential Diagnostic Power of Blood Circular RNA Expression in Active Pulmonary Tuberculosis. EBioMedicine. 2018 Jan;27:18-26.

10、Wang J, Xu C, Zheng Q, Yang K, Lai N, Wang T, Tang H, Lu W. Orai1, 2, 3 and STIM1 promote store-operated calcium entry in pulmonary arterial smooth muscle cells. Cell death discovery. 2017 Nov 27;3:17074.

11、Shu J, Li D, Ouyang H, Huang J, Long Z, Liang Z, Chen Y, Chen Y, Zheng Q, Kuang M, Tang H, Wang J, Lu W. Comparison and evaluation of two different methods to establish the cigarette smoke exposure mouse model of COPD. Scientific reports. Sci Rep. 2017 Nov 13;7(1):15454.

12、Vanderpool RR, Tang H, Rischard F, Yuan JX. Is p38 MAPK a Dark Force in Right Ventricular Hypertrophy and Failure in Pulmonary Arterial Hypertension? American journal of respiratory cell and molecular biology. Am J Respir Cell Mol Biol. 2017 Nov;57(5):506-508.

13、Wu K#, Zhang Q#, Wu X#, Lu W#, Tang H#, Liang Z, Gu Y, Song S, Ayon RJ, Wang Z, McDermott KM, Balistrieri A, Wang C, Black SM, Garcia JGN, Makino A, Yuan JX, Wang J*. Chloroquine is a potent pulmonary vasodilator that attenuates hypoxia-induced pulmonary hypertension. British journal of pharmacology. 2017 Nov;174(22):4155-4172.

14、Tang H, Zheng Q, Wang J. Pathogenic role of ion channels in pulmonary arterial hypertension. Experimental physiology. 2017 Sep 1;102(9):1075-1077.

15、Ren X, Zhang F, Zhao M, Zhao Z, Sun S, Fraidenburg DR, Tang H, Han Y. Angiotensin-(1-7) in Paraventricular Nucleus Contributes to the Enhanced Cardiac Sympathetic Afferent Reflex and Sympathetic Activity in Chronic Heart Failure Rats. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 2017;42(6):2523-2539.

16、Tang H, Vanderpool RR, Wang J, Yuan JX. Targeting L-arginine-nitric oxide-cGMP pathway in pulmonary arterial hypertension. Pulmonary circulation. 2017 Jul-Sep;7(3):569-571.

获奖及个人荣誉：

1、2018 Young Investigator Achievement Award, 2018青年研究者成就奖, 美国心脏病学会科学会,国际学术奖, 2019(汤海洋) (科研奖励)

2、美国医学研究联合会中西部学者奖, 美国医学研究联合会,国际学术奖, 2017

3、ENTELLIGENCE青年科学家奖, 美国胸科协会，ENTELLIGENCE评奖委员会, 国际学术奖, 2016

4、中西部临床与转化研究会年会报告奖, 中西部临床与转化研究会,国际学术奖, 2015

5、医学研究联合会中西部学者奖, 医学研究联合会, 国际学术奖, 2015