职务：

肺纤维化与肺结核病研究方向负责人；肺纤维化学组组长

职称：

教授

研究方向：

肺纤维化与肺结核病

研究领域：

肺纤维化、慢性阻塞性肺疾病等呼吸疾病发病机制；

呼吸道宿主防御机制

代表性学术论文：

1、Xiao Xiao Tang, Lynda Ostedgaard, Mark Hoegger, Thomas Moninger, Phil Karp, James McMenimen, Biswa Choudhury, Ajit Varki, David Stoltz, Michael Welsh. Acidic pH Increases Airway Surface Liquid Viscosity In Cystic Fibrosis (2016). Journal of Clinical Investigation. 126(3):879-91. 

基本科学指标ESI高被引论文（他引次数>100） 

Rated by Nature Index: “In the top 5% of all research outputs scored by Altmetric”

2、Alejandro Pezzulo*, Xiao Xiao Tang* (*共同第一作者), Mark Hoegger, Mahmoud Abou Alaiwa, Shyam Ramachandran, Thomas Moninger, Phillip Karp, Christine Wohlford-Lenane, Henk Haagsman, Martin van Eijk, Botond Bánfi, Alexander Horswill, David Stoltz, Paul McCray, Jr., Michael Welsh, Joseph Zabner. Reduced Airway Surface pH Impairs Bacterial Killing in the Porcine Cystic Fibrosis Lung (2012). Nature 487(7405):109-13. 

ESI高被引论文（他引次数>480） 

Highlighted by Faculty of 1000 Immunology: “Exceptional: New finding; Technical advance”

3、Katrina Muraglia, Rajeev Chorghade, Bo Ram Kim, Xiao Xiao Tang, Viral Shah, Anthony Grillo, Page Daniels, Alexander Cioffi, Philip Karp, Lingyang Zhu, Michael Welsh & Martin Burke. Small-molecule Ion Channels Increase Host Defences in Cystic Fibrosis Airway Epithelia (2019). Nature doi:10.1038/s41586-019-1018-5 (preprint). 

Nature 同期刊登专家深度评论(Commented by David N. Sheppard and Anthony P. Davis, Fighting Cystic Fibrosis with Small Molecules, Nature, 10.1038/d41586-019-00781-y）

4、Viral Shah, David Meyerholz, Xiao Xiao Tang, Leah Reznikov, Mahmoud Abou Alaiwa, Sarah Ernst, Phil Karp, Christine Wohlford-Lanane, Kristopher Heilmann, Mariah Leidinger, Patrick Allen, Joseph Zabner, Paul McCray, Jr., Lynda Ostedgaard, David Stoltz, Christoph Randak, Michael Welsh. Airway Acidification Initiates Host Defense Abnormalities in Cystic Fibrosis Mice (2016). Science. 351(6272): 503-7. 

ESI高被引论文（他引次数>120） 

Highlighted by Faculty of 1000 Microbiology: “Very good: Interesting hypothesis; New finding; Novel drug target”

5、Viral Shah, Sarah Ernst, Xiao Xiao Tang, Phil Karp, Connor Parker, Lynda Ostedgaard, Michael Welsh. Relationships among CFTR Expression, HCO3- Secretion, and Host Defense May Inform Gene- and Cell-Based Cystic Fibrosis Therapies (2016). Proc. Natl. Acad. Sci. 113(19):5382-7. 

Highlighted by Pulmonary Cell News (April 28, 2016) as Top Story

6、Suifang Mao, Alok Shah, Thomas Moninger, Lynda Ostedgaard, Lin Lu, Xiao Xiao Tang, Ian Thornell, Leah Reznikov, Sarah Ernst, Philip Karp, Ping Tan, Shaf Keshavjee, Mahmoud Abou Alaiwa, Michael Welsh. Motile Cilia of Human Airway Epithelia Contain Hedgehog Signaling Components that Mediate Noncanonical Hedgehog Signaling (2018). Proc. Natl. Acad. Sci. 115(6): 1370-1375.

7、Xiao Xiao Tang, Kin Lam Fok, Hao Chen, Kay Sheung Chan, Lai Ling Tsang, Dewi Kenneth Rowlands, Xiao Hu Zhang, Jian Da Dong, Ye Chun Ruan, Xiao Hua Jiang, Sidney Siu Bun Yu, Yiu Wa Chung, and Hsiao Chang Chan. Lymphocyte CFTR Promotes Epithelial Bicarbonate Secretion for Bacterial Killing (2012). J Cell Physiol. 227(12):3887-94.

8、Xiao Xiao Tang, Hao Chen, Sidney Yu, Li Zhang, Michael Caplan, Hsiao Chang Chan. Lymphocytes Accelerate Epithelial Tight Junction Assembly: Role of AMP-activated Protein Kinase (AMPK) (2010). PLoS One 5(8):e12343.

科研项目：

1、国家自然科学基金面上项目（81770015），上皮离子通道CFTR在PM2.5增加呼吸道对细菌易感性中的作用及机制研究（主持）

2、广东省珠江人才计划本土创新科研团队，慢阻肺综合防治创新团队（核心成员）

获奖及个人荣誉：

1、广州市高层次卫生人才（医学重点人才），广州市卫计委，2018

2、广东省杰出青年医学人才，广东省卫健委，2018

3、“南山学者”特聘教授，广州医科大学，2016

4、最佳科学论文竞赛一等奖，美国爱荷华大学，2016

5、最佳基础科学海报奖，美国爱荷华大学，2012

6、最佳基础科学论文摘要入围奖，第26届北美囊性纤维化会议，2012

7、最佳基础科学论文摘要入围奖，第25届北美囊性纤维化会议，2011

8、美国霍华德 · 休斯医学研究所博士后研究基金，霍华德 · 休斯医学研究所，2009

9、全球杰出研究奖学金，香港中文大学，2008

10、青年科学家奖，第6届生命科学前沿国际研讨会，2006

11、青年科学家奖，第5届交叉生命科学国际研讨会，2005

联系方式：

Email: tangxiaoxiao@gird.cn