职称：

教授

研究方向：

重大呼吸系统感染和肺损伤

研究工作：

呼吸道感染的疫苗与抗体研究，主要包括腺病毒、流感病毒、新冠病毒。近来重点研发鼻喷疫苗及其黏膜免疫机制，在抗体组库领域开展探索, 发表多篇抗体组库及抗体研究文章。

科研项目：

1、国家自然科学基金重大专项重点项目：鼻喷疫苗建立呼吸道粘膜免疫屏障及机制研究,项目批准号：92269201，290万

代表性学术论文：

1、An adenovirus-vectored COVID-19 vaccine confers protection from SARS-COV-2 challenge in rhesus macaques, Nature Communications 2020 (2020 NC top 50 SARS-CoV-2 articles)

2、Intranasal booster using an Omicron vaccine confers broad mucosal and systemic immunity against SARS-CoV-2 variants, Signal Transduct Target Ther., 2023

3、SARS-CoV-2 Delta and Omicron variants evade population antibody response by mutations in a single spike epitope, Nature Microbiology, 2022

4、Somatically hypermutated antibodies isolated from SARS-CoV-2 Delta infected patients cross-neutralize heterologous variants, Nature Communications, 2022

5、Broad and durable antibody response after vaccination with inactivated SARS-CoV-2 in individuals with a history of 2003 SARS-CoV infection. Emerging Microbes & Infection. 2022

6、Analysis of B Cell Receptor Repertoires Reveals Key Signatures of the Systemic B Cell Response after SARS-CoV-2 Infection. Journal of Virology 2022

7、A Class of Shark-Derived Single-Domain Antibodies can Broadly Neutralize SARS-Related Coronaviruses and the Structural Basis of Neutralization and Omicron Escape. Small Methods. 2022

8、Germline IGHV3-53-encoded RBD-targeting neutralizing antibodies are commonly present in the antibody repertoires of COVID-19 patients. Emerging Microbes & Infection. 2021

9、Longitudinal Peripheral Blood Transcriptional Analysis Reveals Molecular Signatures of Disease Progression in COVID-19 Patients. Journal of Immunology. 2021

10、Kinetics of SARS-CoV-2 specific IgM and IgG responses in COVID-19 patients. Emerging Microbes & Infection. 2020 (EMI top 50 cited paper)

联系方式：

Email: chen_ling@gibh.ac.cn