李靖-全体研究人员-人才队伍-呼吸疾病全国重点实验室

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人才队伍

全体研究人员 • 学组组长

人才队伍全体研究人员

李靖

职务：

广州医科大学附属第一医院变态反应科主任

职称：

教授

研究方向：

涵盖支气管哮喘、咳嗽、过敏性鼻炎及ABPA等常见或少见的过敏性和慢性呼吸道炎症性疾病

科研项目：

1、国家自然科学基金国际合作项目中国-芬兰-德国特别项目（81261130023）：特定农村环境中儿童期哮喘保护性免疫调节机制的多中心研究。

2、国自然科学基金重大研究课题项目（91542104）：尘螨免疫治疗对呼吸道上皮细胞B防御素和树突状细胞的调节作用。

3、国自然课题项目（81370129）：标准化变应原屋尘螨鼻激发试验对变应性鼻炎或哮喘患者上下气道炎症的影响。

4、国家重点研发精准医学研究课题项目（2016YFC0905800）：呼吸疾病诊疗规范及应用方案的精准化研究（哮喘）

5、广东省科技计划课题项目（2017B020226006）：环境因素对哮喘发病与控制影响的队列研究

6、广州市科技计划课题项目（201607020046）：城乡环境微生物及脂质成分的差异对儿童期哮喘免疫调节机制的研究。

7、广州医科大学高水平大学创新团队培育计划（B185004104）：变态反应疾病创新研究团队

代表性学术论文：

1、Wang, W. and Xian, M. and Xie, Y. and Zheng, J. and Li, J. Aggravation of airway inflammation and hyperresponsiveness following nasal challenge with Dermatophagoides pteronyssinus in perennial allergic rhinitis without symptoms of asthma. [J]. Allergy, 2016, 71(3):378-386.

2、Yang Z, Zheng W, Yung E, Zhong, N and Wong, G. W. K and Li, J. Frequency of food group consumption and risk of allergic disease and sensitization in schoolchildren in urban and rural China[J]. Clinical & Experimental Allergy, 2015, 45(12):1823-1832.

3、Li J, Wang H, Chen Y, Zheng, J. and Wong, G. W. and Zhong, N.. House dust mite sensitization is the main risk factor for the increase in prevalence of wheeze in 13- to 14-year-old schoolchildren in Guangzhou city, China[J]. Clinical & Experimental Allergy, 2013, 43(10):1171-1179.

4、Lai X, Li J, Xiao X,and Liu, E. and Zhang, C. and Wang, H. and Gjesing, B and Zhong, N. and Spangfort, M. D.. Specific IgG4 production during house dust mite immunotherapy among age, gender and allergic disease populations.[J]. International Archives of Allergy & Immunology, 2013, 160(1):37-46.

5、Yan C, Wong G W, Jing L. Environmental Exposure and Genetic Predisposition as Risk Factors for Asthma in China[J]. Allergy Asthma & Immunology Research, 2016, 8(2):92.

6、Li J, Kang J, Wang C, Yang, J. and Wang, L. and Kottakis, I and Humphries, M and Zhong, N.. Omalizumab Improves Quality of Life and Asthma Control in Chinese Patients With Moderate to Severe Asthma: A Randomized Phase III Study[J]. Allergy Asthma & Immunology Research, 2016, 8(4):319.

7、Feng M, Yang Z, Pan L,and Lai, X. and Xian, M. and Huang, X. and Chen, Y. and Schröder, P. C. and Roponen, M and Schaub, B,Wong, G W and Li, J. Associations of early life exposures and environmental factors with asthma among children in rural and urban areas of Guangdong, China.[J]. Chest, 2016, 149(4):1030-1041.

8、Chan, T. F. and Ji, K. M. and Yim, A. K. and Liu, X. Y. and Zhou, J. W. and Li, R. Q. and Yang, K. Y. and Li, J. and Li, M. and Law, P. T，Wu, Y L，Cai, Z L，Qin, Hao，Bao, Ying，Leung, Ross Ka-Kit，Ng, Patrick Kwok-Shing，Zou, Ju，Zhong, X J，Ran, Pi-Xin，Zhong, Nan-Shan，Liu, Zhi-Gang，Tsui, Stephen Kwok-Wing.The draft genome, transcriptome, and microbiome of Dermatophagoides farinae reveal a broad spectrum of dust mite allergens.[J]. Journal of Allergy & Clinical Immunology, 2015, 135(2):539-548.

9、郑文涛,杨朝崴,郑晓宁,李靖. 屋尘提取物暴露对过敏性哮喘的免疫调节机制. 国际呼吸杂志. 2016,36(13):989-993

10、时旭,黄夏飞,谢佳星,张清玲,鲜墨,杨朝崴,顾莹莹,关玉宝,李靖. 肺嗜酸性粒细胞浸润症临床特点的回顾性分析[J]. 中国呼吸与危重监护杂志,2017,16(02):147-154.

11、曾雪妮,李靖. 皮下注射变应原特异性免疫治疗作用机制[J]. 中华临床免疫和变态反应杂志,2013,7(03):272-277.

12、杨朝崴, 郑振宇, 朱丽君, 任霞, 李靖. 锌指蛋白A20在呼吸系统疾病中的作用[J]. 国际呼吸杂志, 2018(6).

13、Feng M, Su Q, Lai X, Xian, Mo and Shi, Xu and Wurtzen, Adler and Qin, Rundong and Zeng, Xiaohui and Li, Jing. Functional and Immunoreactive Levels of IgG4 Correlate with Clinical Responses during the Maintenance Phase of House Dust Mite Immunotherapy. J Immunol. 2018:ji1701690. doi:10.4049/jimmunol.1701690.

14、Yang Z, Zhao J, Wei N,Feng, M. and Xian, M. and Shi, X. and Zheng, Z. and Su, Q. and Wong, G. W.K. and Li, J. Cockroach is a major cross-reactive allergen source in shrimp-sensitized rural children in southern China. Allergy. 2018;73(3):585-592. doi:10.1111/all.13341.

15、Wanjun W, Qiurong H, Yanqing X, Mo X, Nili W, Jing L. Responsiveness of Nasal Provocation Testing—But Not Skin Test and Specific Immunoglobulin E Blood Level—Correlates With Severity of Allergic Rhinitis in Dermatophagoides Species-Sensitized Patients. Am J Rhinol Allergy. 2018:194589241877943. doi:10.1177/1945892418779435.

16、Chen Y, Wang H, Wong GWK, Zhong N, Li J. Allergen sensitization affected the change trend of prevalence of symptoms of rhinitis coexisting with wheeze among adolescents in Guangzhou City from 1994 to 2009. Pediatr Allergy Immunol. 2017;28(4):340-347. doi:10.1111/pai.12709. 17.Bao, Yixiao and Chen, Jianjun and Cheng, Lei and Guo, Yinshi and Hong, Suling and Kong, Weijia and Lai, He and Li, Houyong and Li, Huabin and Li, Jing and Li, Tianying and Lin, Xiaoping and Liu, Shixi and Liu, Z