职称：

教授

研究方向：

主要研究呼吸道粘液纤毛清除系统损伤相关的呼吸疾病，包括慢阻肺、新冠肺炎、原发性纤毛不动症，支气管扩张，哮喘等。包括：1. 疾病状态下粘液纤毛清除系统的损伤机制；2. 疾病状态下粘液纤毛清除系统与免疫系统的通讯 3. 疾病状态下粘液纤毛清除系统异常的早期诊断；4. 恢复/增强粘液纤毛清除功能的药物研发；5. 靶向呼吸道上皮的药物递送系统的开发。

代表性学术论文：

1、Wang, L.*, Paudyal, S., Kang, Y., Owa, M., Liang, F., Spektor, A. Knaut, H., Sánchez, I., and Dynlacht, B. D*. (2021). Regulators of tubulin poly-glutamylation control nuclear shape and cilium disassembly by balancing microtubule and actin assembly. Cell Research. PMID: 34782749.（*共同通讯作者）

2、Wang, L., Failler, M., Fu, W., and Dynlacht, B. D*. (2018). A distal centriolar protein network controls organelle maturation and asymmetry. Nature Communications. PMID: 30258116.

3、Wang, L.*, and Dynlacht, B. D. *(2018). The regulation of cilium assembly and disassembly in development and disease. Development. PMID: 30224385.（*共同通讯作者）

4、Wang, L.#, Lee, K.#, Malonis, R., Sanchez, I., and Dynlacht, B. D*. (2016). Tethering of an E3 ligase by PCM1 regulates the abundance of centrosomal KIAA0586/Talpid3 and promotes ciliogenesis. eLife. PMID: 27146717.

5、Wang, L#., Fu, C.#, Fan, H., Du, T., Dong, M., Chen, Y., Jin, Y., Zhou, Y., Deng, M., Gu, A*., Jing Q. *, Liu T. *, and Zhou Y*. (2013). miR-34b regulates multiciliogenesis during organ formation in zebrafish. Development. PMID: 23698347.

6、Wang, L.#, Zhang, Y.#, Zhou, T., Fu, Y. F., Du, T. T., Jin, Y., Chen, Y., Ren, C. G., Peng, X. L., Deng, M., and Liu, T*. (2008). Functional characterization of lmo2-Cre transgenic zebrafish. Developmental dynamics. PMID: 18627109.

7、Fu, W., Wang, L., Kim, S., Li, J., and Dynlacht, B. D. (2016). Role for the IFT-A complex in selective transport to the primary cilium. Cell Reports. PMID: 27806291

获奖及个人荣誉：

1、DOD Prostate Cancer Research Program, Postdoctoral Training Award, USA, 2016-2018

联系方式：

Email: wangleigoal@163.com