肺动脉高压的发病机制以及肺血管疾病的诊治；肺源性心脏病发生发展的分子机制；肺血管介入技术的研究。

主要科学发现包括：

1、揭示合成和氧化三甲胺是肠道菌群促进肺动脉高压发生发展的重要机制（AJRCMB，2022）。

2、首次发现新型冠状病毒感染患者存在静脉血栓高风险，提出早期识别和干预新冠感染患者的静脉血栓风险，预防肺栓塞（AJRCCM 2021，Lancet Hematology 2020，Crit Care Med 2020）。

3、首创肺源性心脏病大鼠模型并验证机械应力-炎症轴在右心衰竭中的关键作用（Am J Pathol，2025）。

1、国家自然科学专项基金 肺动脉高压的血小板特征及其调控肺血管重塑的机制 项目批准号：82241024。经费：50万 2023-2025

2、国家自然科学基金面上项目 白介素21受体在肺动脉高压肺血管重构中的作用及其机制 项目批准号：81970046。经费：55万 2020-2023

3、国家自然科学基金面上项目 氧化三甲胺通过PERK上调巨噬细胞炎症因子分泌在肺动脉高压中的作用与机制 项目批准号：82270053。经费：52万 2023-2026

4、广东省自然科学基金 VEGF介导的内皮细胞凋亡抵抗化在肺动脉高压中的作用及机制 项目批准号：2021B1515020006 。经费：100万 2021-2024

5、国家科技重大专项 课题 益气活血方治疗慢性血栓栓塞性肺动脉高压的临床评价研究 项目批准号：2023ZD0506605。经费：200万 2024-2028

1、Bai, Q., Liu, H., Wang, H., Yao, Y., Deng, J., & Wang, T（第一通讯作者）. (2026). Clinical research on pulmonary hypertension from a 2025 perspective: A narrative review. Journal of Thoracic Disease, 18(5), 552–552. https://doi.org/10.21037/jtd-2026-1-0340

2、Chen, L., Bai, Q., Tang, R., Cen, C., Luo, Q., Li, H., Lu, W., Liu, C., Ding, S., Wang, J., Hong, C., & Wang, T（第一通讯作者）. (2025). GP IIb/IIIa-ICAM-1 Mediated Platelet-Endothelial Adhesion Exacerbates Pulmonary Hypertension. American Journal of Respiratory Cell and Molecular Biology, 73(3), 383–395. https://doi.org/10.1165/rcmb.2024-0438OC

3、Chen, L., Chen, X., Huang, Y., Ma, Z., Zeng, X., & Wang, T（第一通讯作者）. (2024). Establishment of mouse models for severe pulmonary hypertension through “double-hit” strategies. Experimental Physiology, 109(12), 2026–2030. https://doi.org/10.1113/EP091833

4、Ma, Z., Tong, S., Huang, Y., Wang, N., Chen, G., Bai, Q., Deng, J., Zhou, L., Luo, Q., Wang, J., Lu, W., Chen, L., & Wang, T（第一通讯作者）. (2025). Development and characterization of a novel rat model for emulating chronic obstructive pulmonary disease–associated cor pulmonale. The American Journal of Pathology, 195(5), 831–844. https://doi.org/10.1016/j.ajpath.2025.01.003

5、Wang, X., Chen, G., Bai, Q., Huang, Y., Zhong, K., Ma, Z., Zhang, S., Wang, N., Chen, X., & Wang, T（第一通讯作者）. (2026). Simulating cor pulmonale in chronic obstructive pulmonary disease via cigarette smoke exposure and left pulmonary artery ligation in mice. Physiological Reports, 14(1), e70727. https://doi.org/10.14814/phy2.70727

6、Wang, X., Zeng, W., Bai, Q., Zhong, K., Luo, Q., Deng, J., Cen, C., Wang, K., Li, R., Li, J., Zhang, J., Ye, T., Fang, N., Chen, X., & Wang, T（通讯作者）. (2026). Gut microbiota–derived trimethylamine‐N‐oxide protects pulmonary vascular barrier integrity via vav guanine nucleotide exchange factor 3 (VAV3)‐mediated cytoskeletal remodelling in acute lung injury. British Journal of Pharmacology, 183(15), 4163–4177. https://doi.org/10.1111/bph.70449

7、Yan, M., Chen, X., Li, X., Liu, Q., Yu, B., Cen, Y., Zhang, W., Liu, Y., Li, X., Chen, Y., Wang, T（通讯作者）., & Li, S. (2024). Transferrin receptor-targeted immunostimulant for photodynamic immunotherapy against metastatic tumors through β-catenin/CREB interruption. Acta Pharmaceutica Sinica B, 14(9), 4118–4133. https://doi.org/10.1016/j.apsb.2024.05.030

8、Zeng, X., Ma, Z., Wen, S., Zhou, L., Hong, W., Wu, Z., Cen, C., Bai, Q., Ding, S., Chen, X., Wang, J., Chen, L., Lu, W., & Wang, T（第一通讯作者）. (2025). Imatinib aggravates pressure-overload-induced right ventricle failure via JNK/Runx2 pathway. British Journal of Pharmacology. https://doi.org/10.1111/bph.70006

9、Zeng, X., Wu, Z., Cen, C., Wen, S., Wang, W., Zhou, J., & Wang, T（第一通讯作者）. (2023). Thrombosis is not the only determinant of chronic thromboembolic pulmonary hypertension. International Journal of Cardiology, 392, 131304. https://doi.org/10.1016/j.ijcard.2023.131304

10、Zeng, X., Zhao, R., Wu, Z., Ma, Z., Cen, C., Gao, S., Hong, W., Yao, Y., Wen, K., Ding, S., Wang, J., Lu, W., Wang, X., & Wang, T（第一通讯作者）. (2023). [18 F] -FAPI-42 PET/CT assessment of Progressive right ventricle fibrosis under pressure overload. Respiratory Research, 24(1), 270. https://doi.org/10.1186/s12931-023-02565-5

11、Zhou, L., Bai, Q., Shi, R., Zeng, X., Deng, J., Luo, Q., Wang, X., Zhong, K., Wang, J., Chen, X., & Wang, T（第一通讯作者）. (2026). Cigarette smoke exacerbates pressure overload‐induced right ventricular dysfunction via ALOX15‐mediated ferroptosis. The FASEB Journal, 40(5), e71620. https://doi.org/10.1096/fj.202503718r

12、Chen Lingdan., Tang Ruidi., Chen Hongyuan., Huang Yuhang., Yi Shuting., Bai Qianwen., Zhu Yufan., Hong Cheng., Liu Chunli., Zhang Nuofu., Wang Tao（通讯作者）.(2021). Pulmonary Vasculature: A Target for COVID-19. Am J Respir Crit Care Med, 203(2), 260-261. doi:10.1164/rccm.202009-3564LE

13、Wang Tao., Chen Ruchong., Liu Chunli., Liang Wenhua., Guan Weijie., Tang Ruidi., Tang Chunli., Zhang Nuofu., Zhong Nanshan., Li Shiyue.(2020). Attention should be paid to venous thromboembolism prophylaxis in the management of COVID-19. Lancet Haematol, 7(5), e362-e363. doi:10.1016/S2352-3026(20)30109-5

14、Chen Lingdan., Liu Chunli., Lu Wenju., Wang Tao（第一通讯作者）.(2020). BET Signaling: A Novel Therapeutic Target for Pulmonary Hypertension? Am J Respir Crit Care Med, 201(10), 1313. doi:10.1164/rccm.201912-2525LE

15、Wang Tao., Tang Chunli., Chen Ruchong., Ruan Honglian., Liang Wenhua., Guan Weijie., Sang Ling., Tang Ruidi., Zhong Nanshan., Li Shiyue.(2020). Clinical Features of Coronavirus Disease 2019 Patients With Mechanical Ventilation: A Nationwide Study in China. Crit Care Med, 48(9), e809-e812. doi:10.1097/CCM.0000000000004473

16、Huang Yuhang., Lin Fanjie., Tang Ruidi., Bao Changlei., Zhou Qingxun., Ye Kaiwen., Shen Yi., Liu Chunli., Hong Cheng., Yang Kai., Tang Haiyang., Wang Jian., Lu Wenju., Wang Tao（通讯作者）.(2022). Gut Microbial Metabolite Trimethylamine -Oxide Aggravates Pulmonary Hypertension. Am J Respir Cell Mol Biol, 66(4), 452-460. doi:10.1165/rcmb.2021-0414OC

教授，国家呼吸系统疾病临床研究中心科研部负责人，“广东省杰出青年科学基金”（省杰青）获得者。现任广东省呼吸健康学会肺动脉高压与肺栓塞专业委员会副主任委员、广东省药理学会心血管专业委员会常务委员。主要从事肺动脉高压、肺栓塞等肺血管疾病的临床诊治与转化研究。2009年至2017年在美国学习和工作，获武汉大学与美国乔治亚医学院联合培养博士学位，并在美国弗吉尼亚大学从事血管疾病博士后研究，期间通过 美国执业医师考试（USMLE Step 1–3）。以第一作者、共同第一作者或通讯作者在 Lancet Haematology、ATVB、AJRCMB 等国内外期刊发表论文30余篇。主持国家自然科学基金面上项目、科技部重大专项、广东省自然科学基金杰出青年基金等多项课题，并担任 Journal of Thoracic Disease 编委及 Biomaterials 等国际期刊审稿人。