硕士研究生导师

导师介绍

姓名 寸益贤 性别
民族 白族 导师层次 第四层次
职称 教授 导师类型 硕士生导师
学历 博士研究生 学位 博士
行政职务 邮箱 yixiancun@163.com
招生方向 基础医学
个人简介

长期致力于m6A RNA修饰的研究,课题组与梁文华教授团队紧密合作,聚焦于解析m6A 发生选择性修饰的机理及其功能意义、探究RNA修饰如何调控肺癌早期的发展等。

研究领域

RNA修饰和肺癌

研究成果

科研项目:

1、2026年广州医科大学“高大建”启动经费,2026.6-2031.6,150万,在研,主持

2、国家自然科学基金青年项目,32300455,2024-01-01至2026-12-31,30万,在研,主持

3、广东省区域联合基金-青年基金项目,2022A1515110255,2022-10-01至2025-09-30,10万,主持,已结题

4、高校基本科研业务费-中山大学青年教师培育项目,23ptpy66,2023-01至2023-12,10万,主持,已结题

5、国家自然科学基金面上项目2023-01-01至2026-12-31, 54万元,在研,参与


已发表文章:

1、Ren Z*,He J*, Huang X*, Gao Y*, Wei C*, Wu Z,  Guo W, Wang F, Zhao Q, Sun X, Zhang J, Cao N, Lin L#, Wang J#, Cun Y#. Isoform characterization of m6A in single cells identifies its role in RNA surveillance, Nature Communications, 2025, 16(1):5828.

2、Huang X*, Zhang J*, Cun Y*, Ye M*, Ren Z*, Guo W,Ma X, Liu J, Luo W, Sun X, Shao J, Wu Z, Zhu X, Wang J#.  Spatial control of m6A deposition on enhancer and promoter RNAs through co-acetylation of METTL3 and H3K27 on chromatin, Molecular Cell, 2025, 85(7):1349-1365.(Featured article, previewed by Chuan He)

3、Cun Y*, An S*, Zheng H*, Lan J, Chen W, Luo W, Yao C, Li X, Huang X, Sun X, Wu Z, Hu Y, Li Z, Zhang S, Wu G, Yang M, Tang M, Yu R, Liao X, Gao G, Zhao W, Wang J#, Li J#. Specific regulation of m6A by SRSF7 promotes the progression of glioblastoma, Genomics, Proteomics & Bioinformatics, 2023, 21(4):707-728.

4、Yu P*, Zhou S*, Gao Y, Liang Y, Guo W, Wang DO, Ding S, Lin S#, Wang J#, Cun Y#. Dynamic landscapes of tRNA transcriptomes and translatomes in diverse mouse tissues, Genomics, Proteomics & Bioinformatics, 2023, 21(4):834-849.

5、Cun Y, Guo W, Ma B, Okuno Y, Wang J#. Decoding the specificity of m6A RNA methylation and its implication in cancer therapy, Molecular Therapy, 2024, 32(8):2461-2469.

6、Sun X*, Shao J*, Wu Z*, Ren Z*, Ma X*, Wan X, Huang X, Cun Y#, Wang J#. Unfolded Proteins Drive m6A‑Dependent Paraspeckle Collapse to Facilitate RNA Export. Molecular Cell, 2026, Accept

7、Cun Y, Li J, Ye M, Huang X, Wang J#. Optimized GLORI-seq of chromatin-associated RNAs, Methods in Molecular Biology(Springer Nature出版社,经典实验方法指南丛书),受邀书籍章节,2026,Accept

8、Guo W*, Ren Z*, Huang X*, He J, Liu J, Shao J, Ma X, Wei C, Cun Y, He J, Zhang J, Wu Z, Guo Y, Zhang Z, Feng Z, He J, Wang J#. Single-molecule m6A detection empowered by endogenous labeling unveils complexities across RNA isoforms, Molecular Cell, 2025,85(6):1233-1246.

9、Sun X*, Ren Z*, Cun Y, Zhao C, Huang X, Zhou J, Hu R, Su X, Ji L, Li P, Mak KLK, Gao F, Yang Y, Xu H, Ding J, Cao N, Li S, Zhang W, Lan P, Sun H, Wang J# and Yuan P#. Hippo-YAP signaling controls lineage differentiation of mouse embryonic stem cells through modulating the formation of super-enhancers, Nucleic Acids Research, 2020, 48(13):7182-7196.

10、An S*, Huang W*, Huang X*, Cun Y, Cheng W, Sun X, Ren Z, Chen Y, Chen W, Wang J#. Integrative network analysis identifies cell-specific trans regulators of m6A, Nucleic Acids Research, 2020, 48(4):1715-1729.

11、Zhao B*, Zhang W*, Cun Y, Li J, Liu Y, Gao J, Zhu H, Zhou H, Zhang R, Zheng P#. Mouse embryonic stem cells have increased capacity for replication fork restart driven by the specific Filia-Floped protein complex, Cell Research, 2018, 28(1): 69-89.

课题组风采