导师介绍
| 姓名 | 刘斌 | 性别 | 男 |
| 民族 | 汉族 | 导师层次 | 硕士生导师 |
| 职称 | 教授 | 导师类型 | 学术型 |
| 学历 | 研究生 | 学位 | 博士 |
| 行政职务 | 邮箱 | 2026991005@gzhmu.edu.cn | |
| 招生方向 | |||
广州医科大学“南山学者”优秀人才、特聘教授，呼吸疾病全国重点实验室PI，2025年入选国家自然科学基金优秀青年科学基金项目（海外）。2016年博士毕业于中山大学，2017年起先后在美国伊利诺伊大学芝加哥分校（UIC）和亚利桑那大学（UA）从事博士后研究；2024年起任职于美国圣路易斯华盛顿大学（Washington University in St. Louis）讲师（Instructor）。现为美国心脏协会（AHA）会员、美国胸科学会（ATS）会员、北美血管生物学组织（NAVBO）会员，并担任ATVB、Cancer Letters等多个国际权威期刊审稿人。以第一作者或通讯作者在Circulation（2024）、Arteriosclerosis, Thrombosis, and Vascular Biology（ATVB，2022/2025）、European Respiratory Journal（2022）、Frontiers in Immunology（2022）、Pulmonary Circulation（2022）等国际学术刊物发表论文多篇。主持国家自然科学基金优秀青年科学基金项目（海外）及美国心脏协会基金（AHA Career Development Award）等。多次受邀在AHA、ATVB、Keystone Symposia等国际学术会议做专题报告。
主要研究方向为（1）肺动脉高压与肺血管重塑的分子机制；（2）肺纤维化等重大呼吸系统疾病的内皮细胞功能调控；（3）单细胞与空间转录组学在肺血管疾病中的应用。
1. Hyo-Jin Park, Hyung Joon Cho, Peng Chen, William P Pederson, Bin Liu, Dan Yi, Esther Juarez, Nickolaus Lorson, Amaya Bruner, Xiaomei Xia, Qi Zheng, Nabia Kheshtchin-Kamel, Tara Liu, Sarah Raevens, Michael F Beers, Feng Li, Ruud A W Veldhuizen, Huiping Zhou, Julie G Ledford, Steven M Kawut, Zhiyu Dai, Michael B Fallon. Alveolar Type 2 Cell Dysfunction Is Associated with Bile Acid Alterations in Experimental Hepatopulmonary Syndrome. American Journal of Respiratory Cell and Molecular Biology, aanag067.
2. Bin Liu, Dan Yi, Shuai Li, Karina Ramirez, Xiaomei Xia, Yanhong Cao, Shenfeng Qiu, Mrinalini Kala, Ruslan Rafikov, Haiwei Gu, Vinicio de Jesus Perez, Sarah-Eve Lemay, Christopher Glembotski, Kenneth Knox, Sébastien Bonnet, Vladimir Kalinichenko, Michael Fallon, Olivier Boucherat, Zhiyu Dai. Single-cell and Spatial Transcriptomics Identified Fatty Acid-binding Proteins Controlling Endothelial Glycolytic and Arterial Programming in Pulmonary Hypertension. Arterioscler Thromb Vasc Biol. 2025 Jul;45(7):1145-1165.
3. Bin Liu, Dan Yi, Xiaomei Xia, Karina Ramirez, Hanqiu Zhao, Yanhong Cao, Ankit Tripathi, Ryan Dong, Anton Gao, Hongxu Ding, Shenfeng Qiu, Vladimir V Kalinichenko, You-Yang Zhao, Michael B Fallon, Zhiyu Dai. General Capillary Endothelial Cells Undergo Reprogramming Into Arterial Endothelial Cells in Pulmonary Hypertension Through HIF-2α/Notch4 Pathway. Circulation. 2024 Jul 30;150(5):414-417.
4. Bin Liu, Dan Yi, Karina Ramirez, Xiaomei Xia, Hanqiu Zhao, Michael B. Fallon, Vladimir V. Kalinichenko, Shenfeng Qiu, Zhiyu Dai. Novel Animal Model for Pulmonary Hypertension: Lung Endothelial Specific Deletion of Egln1 in Mice. J Respir Biol Transl Med. 2024 Jun;1(2):10007.
5. Dan Yi, Bin Liu, Hongxu Ding, Shuai Li, Rebecca Li, Jiakai Pan, Karina Ramirez, Xiaomei Xia, Mrinalini Kala, Indrapal Singh, Qinmao Ye, Won Hee Lee, Richard Frye, Ting Wang, Yutong Zhao, Kenneth Knox, Christopher Glembotski, Michael Fallon, Zhiyu Dai. E2F1 Mediates SOX17 Deficiency-Induced Pulmonary Hypertension. Hypertension. 2023; 80:2357–2371.
6. Abdulmomen Ali Mohammed Saleh, Farhan Haider, Haimei Lv, Bin Liu, Jing Xiao, Mingming Zhang, Yuzhen Zheng, Shulan Yang, Haihe Wang. SH3BGRL Suppresses Liver
Tumor Progression through Enhanced ATG5-Dependent Autophagy. J Oncol, 2023 Apr 24;2023:1105042.
7. Jiakai Pan, Bin Liu, Zhiyu Dai. The Role of a Lung Vascular Endothelium Enriched Gene TMEM100. Biomedicines, 2023 Mar 17;11(3):937.
8. Bin Liu, Zhiyu Dai. Fatty Acid Metabolism in Endothelial Cell. Genes. 2022,13, 2301.
9. Bin Liu, Dan Yi, Jiakai Pan, Karina Ramirez, Shuai Li, Ting Wang, Chris Glembotski, Michael Fallon, Joanna Kalucka, Zhiyu Dai. TMEM100, a Lung-Specific Endothelium Gene. Arterioscler Thromb Vasc Biol. 2022 Dec;42(12):1495-1497.
10. Jianqiu Kong, Sihong Lu, Long Zhang, Yuhui Yao, Jie Zhang, Zefeng Shen, Mingli Luo, Bin Liu#, Junjiong Zheng# and Tianxin Lin#. m6A Methylation Regulators as Predictors for Treatment of Advanced Urothelial Carcinoma with Anti-PDL1 Agent. Front Immunol. 2022 Sep 15;13:1014861. (#: co-corresponding author).
11. Bin Liu, Dan Yi, Jingbo Dai, Yi Peng, Rebecca Vanderpool, Maggie M. Zhu, Zhiyu Dai, You-Yang Zhao. Endothelial PHD2 Deficiency Induces Nitrative Stress via Suppression of Caveolin-1 in Pulmonary Arterial Hypertension. Eur Respir J. 2022 Dec 22;60(6):2102643.
12. Bin Liu; Dan Yi; Jiakai Pan; Jingbo Dai; Maggie Zhu; Youyang Zhao; Paul Oh;
Michael Fallon; Zhiyu Dai. Suppression of BMP signaling by PHD2 deficiency in
Pulmonary Arterial Hypertension. Pulm Circ. 2022 Mar 23;12(1):e12056.
13. Zhiyu Dai, Jianding Cheng, Bin Liu, Dan Yi, Anlin Feng, Ting Wang, Lingling An, Chen Gao, Yibin Wang, Maggie M. Zhu, Xianming Zhang, You-Yang Zhao. Loss of Endothelial Hypoxia Inducible Factor-Prolyl Hydroxylase 2 Induces Cardiac
Hypertrophy and Fibrosis. J Am Heart Assoc. 2021 Nov 16;10(22):e022077.
14. Dan Yi, Bin Liu, Ting Wang, Qi Liao, Maggie M. Zhu, You-Yang Zhao and Zhiyu Dai. Endothelial Autocrine Signaling through CXCL12/CXCR4/FoxM1 Axis Contributes to Severe Pulmonary Arterial Hypertension. Int. J. Mol. Sci. 2021 Mar,
20;22(6):3182.
15. Bin Liu*, Julio Ricarte Filho*, Apurva Mallisetty, Cassandra Villani, Anastasia
Kottorou, Kristen Rodgers, Chen Chen, Tomoaki Ito, Kyla Holmes, Nicole Gastala,
Klara ValyiNagy, Odile David, Ron C. Gaba, Christian Ascoli, Mary Pasquinelli,
Lawrence E. Feldman, Malek G. Massad, Tza-Huei Wang, Ignacio Jusue-Torres,
Enrico Benedetti, Robert A. Winn, Malcolm V. Brock, James G. Herman, Alicia
Hulbert. Detection of promoter DNA methylation in urine and plasma aids the
detection of non-small cell lung cancer. Clin Cancer Res. 2020 Aug 15; 26 (16): 4339-4348. (* co-first author).
16. Lu Gong, Qinghe Zhang, Xiao Pan, Shuming Chen, Lina Yang, Bin Liu, Weijun Yang, Luyang Yu, Zhi-Xiong Xiao, Xin-Hua Feng, Haihe Wang, Zhi-Min Yuan, Jinrong Peng, Wei-Qiang Tan, Jun Chen. p53 Protects Cells From Death at the Heatstroke Threshold Temperature. Cell Rep. 2019 Dec 10; 29(11):3693-3707.
17. Xu L, Zhang M, Li H, Guan W, Liu B, Liu F, Wang H, Li J, Yang S, Tong X, Wang H. SH3BGRL as a novel prognostic biomarker is down-regulated in acute myeloid
leukemia. Leuk Lymphoma. 2017 Jul 6:1-13.
18. Wenliang Zhang, Mingming Zhang, Bin Liu, Hongshun Shi, Haihe Wang. Optimal timing of autophagy occurrence induced by earle's balanced salts solution in DLD-1, HCT-116, A2780, CHO, Hep G2 and SMMC7721 cancer cell lines. Acta Scientiarum Naturalium Universitatis Sunyatseni. 2016 Jul; 55(4).
19. H. Wang#, B. Liu#, A.Q. Al-Aidaroos#, H. Shi, L. Li, K. Guo, J. Li, B.C. Tan, J.M. Loo, J.P. Tang, M. Thura, Q. Zeng. Dual-faced SH3BGRL: oncogenic in mice, tumor
suppressive in humans. Oncogene. 2016 Jun 23;35(25):3303-13. (# co-first
author).
20. B. Liu, M. Zhang, F. Tong, S. Yang and H. Wang. Expression patterns and
physiological roles of SH3BGR protein family as adaptor proteins. Integr Cancer
Sci Therap. 2016 Mar; 3(2): 410-13.
21. W. Zhang, H. Shi, M. Zhang, B. Liu, S. Mao, L. Li, F. Tong, G. Liu, S. Yang, H. Wang. Poly C binding protein 1 represses autophagy through downregulation of LC3B to promote tumor cell apoptosis in starvation. Int J Biochem Cell Biol 2016 Apr; 73: 127-36.
22. S. Qu, B. Liu, X. Guo, H. Shi, M. Zhou, L. Li, S. Yang, X. Tong, H. Wang. Independent oncogenic and therapeutic significance of phosphatase PRL-3 in FLT3-ITD -negative acute myeloid leukemia. Cancer. 2014 Jul; 120 (14): 2130-41.
