全体研究人员
名字:朱爱如
职务:
职称:教授
研究方向: 重大呼吸系统感染与黏膜免疫
联系方式:zhuairu14@163.com
研究工作

聚焦新发突发病毒性传染病感染免疫,阐明不同呼吸道病原(新冠、流感等)感染与疫苗接种诱导的人群呼吸道黏膜区域与系统免疫的共性规律和差异特征,及其在疾病发生发展中的作用;解析呼吸道黏膜免疫应答的关键调控因子及其调控机制。


科研项目

1、国家自然科学基金委员会,重大研究计划培育项目,92569105,新冠病毒感染与鼻喷疫苗免疫人群上呼吸道免疫应答动态规律研究,2026.01.01-2028.12.31,主持

2、国家自然科学基金委员会,青年科学基金项目,82201933,肺内新冠病毒特异性T细胞应答在疾病转归中的作用及机制研究,2023-01-01 至 2025-12-31,主持

3、呼吸疾病全国重点实验室自主课题,SKLRD-Z-202330,肺内新冠病毒特异性T细胞应答在疾病转归中的作用及机制研究,2023-01至2025-12,主持


代表性成果

1、Zhu A#, Chen Z#, Yan Q#, Jiang M#, Liu X#, Li Z#, Li N#, Tang C#, Jian W#, He J, Chen L, Cheng J, Chen C, Tang T, Xu Z, Hu Q, Li F, Wang Y, Sun J, Zhuang Z, Wen L, Zhuo J, Liu D, Zhang Y, Huang X, Li S, Zeng Q, Chen F, Zhou L, Liu D, Zhong C, Chen Y, Li S, Liang K, Zhong N, Zhang X, Chen J, Chen X*, Xu Y*, Zhong N*, Zhao J*, Zhao J*. Robust mucosal SARS-CoV-2-specific T cells effectively combat COVID-19 and establish polyfunctional resident memory in patient lungs. Nat Immunol. 2025 Mar;26(3):459-472. (IF=27.7)

2、Wang Y#, Cai R#, Zhu A#, Chen J, Chen C, Zhou L, Xing X, Zhong Q, Wei P, Li X, Zhang Z, Zhang Y, Chen L, Gao J, Li S, Xiong X, Qu B, Huang S, Lin Z, Bai H, Hu Q, Zhao J, Shi Y, Yang Y, Qin P, Zhang L, Zhao J. Immune profiling of mpox survivors reveals divergent durability of antibody and T cell responses. Nat Commun. 2025 Dec 4. doi: 10.1038/s41467-025-67266-7. Epub ahead of print. PMID: 41345407. (IF=15.7)

3、Zhang J#, Zhu A#, Wei S, Shi Y, Chen C, Huang T, Tang T, Zhao J, Cai Y, Han C, Zhao J, Wang Y. Identification of Pan-Coronavirus Neutralizing Aptamers Through CRISmers Targeting the Conserved Fusion Peptide. Adv Healthc Mater. 2025 Aug;14(21):e2501869. (IF=9.6)

4、Chen Z#, Yuan Y#, Hu Q#, Zhu A#, Chen F, Li S, Guan X, Lv C, Tang T, He Y, Cheng J, Zheng J, Hu X, Zhao J*, Zhao J*, Sun J*. SARS-CoV-2 immunity in animal models. Cell Mol Immunol. 2024 Feb;21(2):119-133. (IF=21.8)

5、Zhao H#, Zhang NN#, Hannawi S#, Zhu AR#, Xiong XC, Huang YJ, Yu DD, Chen CJ, Dai J, Abuquta A, Ying B*, Zhao JC*, Qin CF*. Neutralization of Omicron XBB.1 by booster vaccination with BA.4/5 monovalent mRNA vaccine. Cell Discov. 2024 Jan 9;10(1):7. (IF=13.0)

6、Zhu A#, Wei P#, Man M#, Liu X#, Ji T#, Chen J, Chen C, Huo J*, Wang Y*, Zhao J*. Antigenic characterization of SARS-CoV-2 Omicron subvariants XBB.1.5, BQ.1, BQ.1.1, BF.7 and BA.2.75.2. Signal Transduct Target Ther. 2023 Mar 15;8(1):125. (IF=52.7)

7、Qiu S#, Chen Z#, Zhu A#, Zeng Q#, Liu H#, Liu X, Ye F, Jin Y, Wu J, Yang C, Wang Q, Chen F, Chen L, Tian S, Du X, Hu Q, Cheng J, Chen C, Li F, Sun J, Wang Y, Zhao J*, Zhao J*, Song H*. Successful clearance of persistent SARS-CoV-2 asymptomatic infection following a single dose of Ad5-nCoV vaccine. Signal Transduct Target Ther. 2023 Mar 15;8(1):123. (IF=52.7)

8、Zhang J#, Zhu A#, Mei M, Qu J, Huang Y, Shi Y, Xue M, Zhang J, Zhang R*, Zhou B*, Tan X*, Zhao J*, Wang Y*. Repurposing CRISPR/Cas to Discover SARS-CoV-2 Detecting and Neutralizing Aptamers. Adv Sci (Weinh). 2023 Aug;10(22):e2300656. (IF=14.3)

9、Liu D#, Chen C#, Chen D#, Zhu A#, Li F#, Zhuang Z, Mok CKP, Dai J, Li X, Jin Y, Chen Z, Sun J, Wang Y, Li Y, Zhang Y, Wen L, Zhang Z, Zhuo J, Wang J, Ran W, Wang D, Zhang S, Tang Y, Li S, Lai X, Wei P, Yuan J, Chen F, Huang S, Sun F, Qian Z, Tan W, Zhao J*, Peiris M*, Zhao J*. Mouse models susceptible to HCoV-229E and HCoV-NL63 and cross protection from challenge with SARS-CoV-2. Proc Natl Acad Sci U S A. 2023 Jan 24;120(4):e2202820120. (IF=9.4)

10、Mok CKP#, Zhu A#, Zhao J#, Lau EHY, Wang J, Chen Z, Zhuang Z, Wang Y, Alshukairi AN, Baharoon SA, Wang W, Tan W, Liang W, Oladipo JO, Perera RAPM, Kuranga SA, Peiris M*, Zhao J*. T-cell responses to MERS coronavirus infection in people with occupational exposure to dromedary camels in Nigeria: an observational cohort study. Lancet Infect Dis. 2021 Mar;21(3):385-395. (IF=36.4)

11、Sun J#, Zhu A#, Li H#, Zheng K#, Zhuang Z#, Chen Z#, Shi Y#, Zhang Z#, Chen SB#, Liu X#, Dai J, Li X, Huang S, Huang X, Luo L, Wen L, Zhuo J, Li Y, Wang Y, Zhang L, Zhang Y, Li F, Feng L, Chen X, Zhong N, Yang Z*, Huang J*, Zhao J*, Li YM*. Isolation of Infectious SARS-CoV-2 from Urine of a COVID-19 Patient. Emerg Microbes Infect. 2020 Apr 28:1-8. (IF=8.4)

12、Sun J#, Zhuang Z#, Zheng J#, Li K#, Wong RL#, Liu D#, Huang J#, He J#, Zhu A#, Zhao J#, Li X#, Xi Y#, Chen R, Alshukairi AN, Chen Z, Zhang Z, Chen C, Huang X, Li F, Lai X, Chen D, Wen L, Zhuo J, Zhang Y, Wang Y, Huang S, Dai J, Shi Y, Zheng K, Leidinger MR, Chen J, Li Y, Zhong N, Meyerholz DK, McCray PB Jr*, Perlman S*, Zhao J*. Generation of a Broadly Useful Model for COVID-19 Pathogenesis, Vaccination, and Treatment. Cell. 2020 Jun 10:S0092-8674(20)30741-8. (IF=45.5)