职务：

广州医科大学联合生命科学学院副院长

职称：

教授

研究方向：

慢性气道疾病

研究工作：

主要研究免疫细胞的发育分化的转录和表观遗传调控及其在炎症性疾病发生发展中的作用和防治策略，从转录、代谢和表观遗传调控等层面揭示免疫细胞在肺损伤和哮喘中作用机制。

科研项目：

1、Li15.国家自然科学基金面上项目，肺泡损伤修复再生的代谢和表观遗传的调控机制研究，2024.1-2027.12，批准号：32370894，负责人，50万，在研

2、国家重点研发计划，表观遗传修饰对肠道免疫系统发育和稳态的调节，2022.1-2026.12，批准号：2021YFA080047，研究骨干，148.65万，在研

3、铁元素依赖的细胞命运调控新机制，浙江省自然科学奖一等奖，2023（第四完成人）

代表性学术论文：

1、Qian G#*, Jiang W#, Sun D#, Sun Z#, Chen A, Fang H, Wang J, Liu Y, Yin Z, Wei H, Fang H*, Zhang X*. B-cell-derived IL-10 promotes allergic sensitization in asthma regulated by Bcl-3. Cell Mol Immunol. 2023 Nov;20(11):1313-1327. (Co-corresponding author)

2、Sun Z#, Chen A#, Fang H#, Sun D, Huang M, Chen E, Luo M, Zhang X*, Fang H*, Qian G*. B cell-derived IL-10 promotes the resolution of lipopolysaccharide-induced acute lung injury. Cell Death Dis. 2023 Jul 13; 14:418 (Co-corresponding author)

3、Zhang H#, Hu Y#, Liu D#, Liu Z, Xie N, Liu S, Zhang J, Jiang Y, Li C, Wang Q, Chen X, Ye D, Sun D, Zhai Y, Yan X, Liu Y, Chen D, Huang X, Chin Y, Shi Y, Wu B*, Zhang X*. The histone demethylase Kdm6b regulates the maturation and cytotoxicity of TCRαβ+CD8αα+ intestinal intraepithelial lymphocytes. Cell Death Differ. 2022 Jul;29(7):1349-1363. (Co-corresponding author)

4、Hu Y#, Zhang H#, Xie N, Liu D, Jiang Y, Liu Z, Ye D, Liu S, Tao Y, Chen X, Li C, Wang Q, Li L, Jiang W, You Q, Huang X, Liu Y, Zhang X*. Bcl-3 promotes TNF-induced hepatocyte apoptosis by regulating the deubiquitination of RIP1. Cell Death Differ. 2022 Jun;29 (6):1176-1186 (Corresponding author)

5、Sun D#, Xie N#, Wang X#, Wu W, Li XY, Chen X, Qian G, Li C, Zhang H, Jiang Y, Ye D, Liu D, Hu Y, Wang J, Chen W, Zhao Q, Zeng M, Zhang J, Wang L*, Zhang X*. Serum RelB is correlated with renal fibrosis and predicts chronic kidney disease progression. Clin Transl Med. 2021;11(5):e362. (Co-corresponding author)

6、Shen J#, Hu L#, Yang L, Zhang M, Sun W, Lu X, Lin G, Huang C*, Zhang X*, Chin YE*. Reversible acetylation modulates dishevelled-2 puncta formation in canonical Wnt signaling activation. Signal Transduct Target Ther. 2020;5(1):115. (Co-corresponding author)

7、Liu Z#, Zhang H#, Hu Y#, Liu D, Li L, Li C, Wang Q, Huo J, Liu H, Xie N, Huang X, Liu Y, Chen CD, Shi Y, Zhang X*. Critical role of histone H3 lysine 27 demethylase Kdm6b in the homeostasis and function of medullary thymic epithelial cells. Cell Death Differ. 2020;27(10): 2843-55. (Corresponding author)

8、Chen X#, Wang C#, Jiang Y, Wang Q, Tao Y, Zhang H, Zhao Y, Hu Y, Li C, Ye D, Liu D, Jiang W, Chin EY, Chen S, Liu Y, Wang M, Liu S*, Zhang X*. Bcl-3 promotes Wnt signaling by maintaining the acetylation of beta-catenin at lysine 49 in colorectal cancer. Signal Transduct Target Ther. 2020;5(1):52. (Co-corresponding author)

9、Jiang Y#, Li C#, Wu Q#, An P, Huang L, Wang J, Chen C, Chen X, Zhang F, Ma L, Liu S, He H, Xie S, Sun Y, Liu H, Zhan Y, Tao Y, Liu Z, Sun X, Hu Y, Wang Q, Ye D, Zhang J, Zou S, Wang Y, Wei G, Liu Y, Shi Y, Eugene Chin Y, Hao Y, Wang F*, Zhang X*. Iron-dependent histone 3 lysine 9 demethylation controls B cell proliferation and humoral immune responses. Nat Commun. 2019;10(1):2935. (Co-corresponding author)

10、Tao Y#, Liu Z#, Hou Y#, Wang S, Liu S, Jiang Y, Tan D, Ge Q, Li C, Hu Y, Liu Z, Chen X, Wang Q, Wang M*, Zhang X*. Alternative NF-kappaB signaling promotes colorectal tumorigenesis through transcriptionally upregulating Bcl-3. Oncogene. 2018;37(44):5887-900. (Co-corresponding author)

11、Liu S#, Sun X#, Wang M#, Hou Y, Zhan Y, Jiang Y, Liu Z, Cao X, Chen P, Liu Z, Chen X, Tao Y, Xu C, Mao J, Cheng C, Li C, Hu Y, Wang L, Chin YE, Shi Y, Siebenlist U, Zhang X*. A microRNA 221- and 222-mediated feedback loop maintains constitutive activation of NFkappaB and STAT3 in colorectal cancer cells. Gastroenterology. 2014;147(4):847-59 e11. (Corresponding author)

12、Wang S, Liu Z, Wang L, Zhang X*. NF-κB signaling pathway, inflammation and colorectal cancer. Cell Mol Immunol. 2009;6(5):327-34. (Corresponding author)

13、Zhang X, Wang H, Claudio E, Brown K, Siebenlist U. A role for the IkappaB family member Bcl-3 in the control of central immunologic tolerance. Immunity. 2007;27(3):438-52.

14、Zhang X, Zhang L, Devadas S, Li L, Keegan AD, Shi Y*. Reciprocal expression of TRAIL and CD95L in Th1 and Th2 cells: role of apoptosis in T helper subset differentiation. Cell Death Differ.

联系方式：

Email: xrzhang@gzhmu.edu.cn