职称：

教授

研究方向：

间质性肺病和肺血管病

研究工作：

血管稳态的调控机制及新型药物和治疗手段的开发：

1、免疫失衡与肺血管疾病

2、代谢紊乱与肺血管疾病

3、肺血管疾病的干细胞治疗

4、肺血管疾病创新药物开发

代表性学术论文：

1、Meng Z*, Zhang S*, Li W*, Wang Y, Wang M, Liu X, Liu CL, Liao S, Liu T, Yang C, Lindholt J, Rasmussen L, Obel L, Stubbe J, Diederichsen A, Sun Y, Chen Y, Yu P, Libby P, Shi GP, Guo J. Cationic proteins from eosinophils bind bone morphogenetic protein receptors promoting vascular calcification and atherogenesis. Eur Heart J. 2023 Aug 1;44(29):2763-2783.

2、Meng Z*, Yu Y*, Zhang Y, Yang X, Lv X, Guan F, Hatch GM, Zhang M, Chen L. Highly bioavailable Berberine formulation improves Glucocorticoid Receptor-mediated Insulin Resistance via reduction in association of the Glucocorticoid Receptor with phosphatidylinositol-3-kinase. Int J Biol Sci. 2020 Jul 19;16(14):2527-2541.

3、Meng Z*, Gwag T*, Sui Y, Park SH, Zhou X, Zhou C. The atypical antipsychotic quetiapine induces hyperlipidemia by activating intestinal PXR signaling. JCI Insight. 2019 Feb 7; 4(3). pii: 125657.

4、Meng Z, Hernandez R, Liu J, Gwag T, Lu W, Marcus Kaul, Hsiai T, Zhou T, Zhou C. HIV Protein Tat Induces Macrophage Dysfunction and Atherosclerosis Development in Low-Density Lipoprotein Receptor-Deficient Mice. Cardiovasc Drugs Ther. 2021 Jan 18; 10.1007/s10557-021-07141-x.

5、Gwag T*, Meng Z*, Sui Y, Helsley RN, Park SH, Wang S, Greenberg RN, Zhou C. Non-nucleoside reverse transcriptase inhibitor efavirenz activates PXR to induce hypercholesterolemia and hepatic steatosis. J Hepatol. 2019 Jan 21. pii: S0168-8278(19)30029-7.

6、Liu T*, Meng Z*, Liu J*, Li J, Zhang Y, Deng Z, Luo S, Wang M, Huang Q, Zhang S, Fendt P, Devouassoux J, Li D, McKenzie ANJ, Nahrendorf M, Libby P, Guo J, Shi GP. Group 2 innate lymphoid cells protect mouse heart from myocardial infarction injury via interleukin 5, eosinophils, and dendritic cells. Cardiovasc Res. 2022 Sep 5: cvac144.

7、Satta S*, Meng Z*, Hernandez R, Cavallero S, Zhou T, Hsiai TK, Zhou C. An engineered nano-liposome-human ACE2 decoy neutralizes SARS-CoV-2 Spike protein-induced inflammation in both murine and human macrophages. Theranostics. 2022; 12(6):2639-2657.

8、Sui Y*, Meng Z*, Chen J, Liu J, Hernandez R, Gonzales M, Gwag T, Morris A, Zhou C. Effects of Dicyclohexyl Phthalate Exposure on PXR Activation and Lipid Homeostasis in Mice. Environ Health Perspect. 2021 Dec;129(12):127001.

获奖及个人荣誉：

1、2022 Harvard Lerner Research poster, first place.

联系方式：

Email: mengzj@gzhmu.edu.cn