研究方向：
1、单细胞及时空多组学数据解码与复杂调控网络研究；
2、抗肿瘤免疫治疗的多重免疫调控机制及早期肺癌演进规律研究；
3、人工智能算法的开发及其在疾病模型中的应用。
研究工作：
长期从事以大数据解析为主导的基础与临床相结合的多学科交叉研究工作，共发表SCI论文50 余篇。其中，其中（共同）第一和通讯作者论文 20 篇，包含Cell (2篇)、Nature、Nature Methods、Nature Review Genetics、Nature Communications等。研究成果入选“中国生命科学十大进展”及“中国生物信息学十大进展”。主持国家自然科学基金和广东省科学基金等项目。
科研项目：
1、国家自然科学基金-面上项目 基于单细胞组学数据研究肿瘤免疫治疗诱发黏膜交互器官炎症副作用的机制 32370972 50万 主持 在研
2、广东省自然科学基金-杰出青年项目 新型组学大数据驱动的肿瘤免疫治疗调控机制研究 2024B1515020052 100万 主持 在研
3、国家重点研发计划青年科学家项目 面向肺癌精准医疗的多模态肿瘤类器官芯片开发与智能决策系统构建 2024YFF0509000 400万 子课题负责人 在研
代表性学术论文：
1、Xianfa Yang^; Bingbing Xie^; Penglei Shen^; Yingying Chen^; Chunjie Li; Fengxiang Tan; Yumeng Yang; Yun Yang; Rui Song; Panpan Mi; Zhiwen Liu; Mingzhu Wen; Patrick P. L. Tam; Shengbao Suo#;Naihe Jing#.2026.Integrated multi-omic atlas reveals the hierarchy of spatiotemporal regulatory networks of mouse gastrulation. Nature Communications. 17:1572.
2、Yanping Lu^; Yuyan Wang^; Meng Xu; Bingbing Xie; Yumeng Yang; Haodong Xu#; Shengbao Suo#. 2026. Assessment of computational methods in predicting TCR–epitope binding recognition. Nature Methods. 23:248-259.
3、Xinqing Lin^; Chunjie Li^; Jiaxi Deng^; Ying Wu; Bingbing Xie; Jingyi Bao; Wenwei Mo; Changhao Zhong; Haiyi Deng; Qingjun Pan; Yuan Qiu; Yuwen He; Shiyue Li; Jia Li; Shengbao Suo#; Chengzhi Zhou#. 2025. Uncovering the immune mechanisms underlying the emergence of immunotherapy-induced pneumonitis in lung cancer patients. Nature Communications. 16:11645.
4、Jincan Ke^;Jian Xu; Jia Liu; Yumeng Yang; Chenkai Guo; Bingbing Xie; Guizhong Cui; Guangdun Peng#; Shengbao Suo#. 2025. High-resolution mapping of single cells in spatial context. Nature Communications. 16:6533.
5、Shengbao Suo#. 2024. Endogenous retroviruses:unveiling new targets for cancer immunotherapy. Nature Reviews Genetics.25(12):827.
6、Fangfang Qu^; Wenjia Li^; Jian Xu^; Ruifang Zhang; Jincan Ke; Xiaodie Ren; Xiaogao Meng; Lexin Qin; Jingna Zhang; Fangru Lu; Xin Zhou; Xi Luo; Zhen Zhang; Minhan Wang; Guangming Wu; Duanqing Pei; Jiekai Chen; Guizhong Cui#; Shengbao Suo#; Guangdun Peng#.2023.Three-dimensional molecular architecture of mouse organogenesis.Nature Communications.14(1):4599.
7、Adrienne M. Luoma^; Shengbao Suo^#; Yifan Wang; Lauren Gunasti; Caroline B.M. Porter; Nancy Nabilsi; Jenny Tadros; Andrew P. Ferretti; Sida Liao; Cagan Gurer; Yu-Hui Chen; Shana Criscitiello; Cora A. Ricker; Danielle Dionne; Orit Rozenblatt-Rosen; Ravindra Uppaluri; Robert I. Haddad; Orr Ashenberg; Aviv Regev; Eliezer M. Van Allen; Gavin MacBeath; Jonathan D. Schoenfeld#; Kai W. Wucherpfennig#.2022.Tissue-resident memory and circulating T cells are early responders to pre-surgical cancer immunotherapy.Cell.185(16):2918-2935.
8、Adrienne M. Luoma^; Shengbao Suo^; Hannah L. Williams; Tatyana Sharova; Keri Sullivan; Michael Manos; Peter Bowling; F. Stephen Hodi; Osama Rahma; Ryan J. Sullivan; Genevieve M. Boland; Jonathan A. Nowak; Stephanie K. Dougan; Michael Dougan#; Guo-Cheng Yuan; Kai W. Wucherpfennig#.2020.Molecular pathways of colon inflammation induced by cancer immunotherapy.Cell. 182(3):655-671.
9、Guangdun Peng^#; Shengbao Suo^; Guizhong Cui^; Fang Yu^; Ran Wang; Jun Chen; Shirui Chen; Zhiwen Liu; Guoyu Chen; Yun Qian; Patrick P.L.Tam; Jing-Dong J.Han#; Naihe Jing#.2019.Molecular architecture of lineage allocation and tissue organization in early mouse embryo.Nature.572(7770):528-532.
10、Shengbao Suo; Qian Zhu; Assieh Saadatpour; Lijiang Fei; Guoji Guo; Guo-Cheng Yuan#.2018.Revealing the critical regulators of cell identity in the mouse cell atlas.Cell Reports. 6(25):1436-1445.
获奖及个人荣誉：
1、国家重大人才工程-青年拔尖人才
2、广东省杰出青年
联系方式：
Email: suo_shengbao@gzlab.ac.cn
孙丽红
