彭杨
职称:
教授、
研究方向:
慢性气道疾病
研究工作:
研究紧密结合临床诊疗需求,通过原代气道上皮细胞培养、多重免疫荧光染色、扫描/透射电镜、高通量测序、功能实验和动物实验等多维检测手段,聚焦上皮细胞损伤参与多种呼吸道疾病(慢性阻塞性肺疾病、慢性鼻窦炎、变应性鼻炎、病毒感染和支气管哮喘等)发展过程的相关机制。
科研项目:
1、NQO1参与调控新冠病毒在鼻上皮纤毛细胞中复制过程的机制研究,国家自然科学基金青年科学基金项目,2024/01-2026/12,主持,30万元;
2、ADAM28调控Hedgehog通路参与鼻息肉上皮纤毛细胞分化异常的机制研究,中国博士后科学基金面上资助,2022/06-2023/06,主持,8 万元;
3、感觉神经环路及TRPA1在变应性鼻炎相关咳嗽高敏感性中的作用及机制研究, 国家自然科学基金面上项目,2024/01-2026/12,参与,53万元;
4、Hippo通路在H3N2病毒感染并损伤鼻腔上皮纤毛中的作用及机制研究, 国家自然科学基金面上项目,2019/01-2022/12, 参与,60万元。
代表性学术论文:
1、Peng Y#, Zi XX#, Tian TF#, et al. Whole-transcriptome sequencing reveals heightened inflammation and defective host defence responses in chronic rhinosinusitis with nasal polyps. European Respiratory Journal (2019)
2、Peng Y#, Chen SY#, Wang ZN# et al. Dicoumarol is an effective post-exposure prophylactic for SARS-CoV-2 Omicron infection in human airway epithelium. Signal Transduction and Targeted Therapy (2023)
3、Peng Y#, Wang ZN#, Chen SY# et al. Angiotensin-converting enzyme 2 in peripheral lung club cells modulates the susceptibility to SARS-CoV-2 in chronic obstructive pulmonary disease. American Journal of Physiology-Lung Cellular and Molecular Physiology (2022)
4、Peng Y#, Guan W#, Tan KS et al. Aberrant localization of FOXJ1 correlates with the disease severity and comorbidities in patients with nasal polyps. Allergy, Asthma & Clinical Immunology (2018)
5、Peng Y#, Chen Z#, Guan W# et al. Down-regulation and aberrant localization of Forkhead-box J1 in allergic nasal mucosa. International Archives of Allergy and Immunology (2018)
6、Peng Y#, Guan W#, Zhu Z# et al. Microarray Assay Reveals Ciliary Abnormalities of the Allergic Nasal Mucosa. American Journal of Rhinology & Allergy (2020)
7、Peng Y#, Wang ZN#, Xu AR# et al.Mucus Hypersecretion and Ciliary Impairment in Conducting Airway Contribute to Alveolar Mucus Plugging in Idiopathic Pulmonary Fibrosis. Frontiers in Cell and Developmental Biology (2022)
8、Peng Y#, Xu AR#, Chen SY# et al. Aberrant Epithelial Cell Proliferation in Peripheral Airways in Bronchiectasis. Frontiers in Cell and Developmental Biology (2020)
联系方式:
Email: pengyang0121@163.com