研究员

研究方向：

重大呼吸系统感染和肺损伤

研究工作：

从事针对重要呼吸道病原相关的疫苗研发，并以此为基础进行底层免疫机制探索，尤其聚焦于呼吸道黏膜免疫诱导和效应机制，探索黏膜免疫细胞动态调控共性规律，指导疫苗理性设计，开发黏膜靶向的新型病毒载体，以期获得更安全、更高效、更广谱、更持久的疫苗。

科研项目：

1、国家青年人才项目，快速、高效、广谱病毒疫苗研发新策略研究 主持 300万 2023.0-2025.12

2、国家自然科学基金委，新冠疫苗序贯接种较同源接种免疫原性 主持 53万 2024.01-2027.12

代表性学术论文：

1、Yu J*, Collier AY*, Rowe M, Mardas F, Ventura JD, Wan H, Miller J, Powers O, Chung B, Siamatu M, Hachmann NP, Surve N, Nampanya F, Chandrashekar A, Barouch DH. 2022. Neutralization of the SARS-CoV-2 Omicron BA.1 and BA.2 Variants. N Engl J Med 386:1579-1580. (* co-first author)

2、J. Yu*, L. H. Tostanoski*, L. Peter*, N. B. Mercado*, K. McMahan*, S. H. Mahrokhian*, J. P. Nkolola*, J. Liu*, Z. Li, A. Chandrashekar, et al., DNA vaccine protection against SARS-CoV-2 in rhesus macaques. Science 369, 806-811 (2020). (* co-first author)

3、J. Yu*, L. H. Tostanoski*, N. B. Mercado*, K. McMahan*, J. Liu*, C. Jacob-Dolan*, A. Chandrashekar*, C. Atyeo, D. R. Martinez, T. Anioke, E. A. Bondzie, A. Chang, S. Gardner, V. M. Giffin, D. L. Hope, F. Nampanya, J. Nkolola, S. Patel, O. Sanborn, D. Sellers, H. Wan, T. Hayes, K. Bauer, L. Pessaint, D. Valentin, Z. Flinchbaugh, R. Brown, A. Cook, D. Bueno-Wilkerson, E. Teow, H. Andersen, M. G. Lewis, A. J. Martinot, R. S. Baric, G. Alter, F. Wegmann, R. Zahn, H. Schuitemaker, D. H. Barouch, Protective efficacy of Ad26.COV2.S against SARS-CoV-2 B.1.351 in macaques. Nature 596, 423-427 (2021); published online EpubAug (10.1038/s41586-021-03732-8). (* co-first author)

4、G. Alter*, J. Yu*, J. Liu*, A. Chandrashekar*, E. N. Borducchi*, L. H. Tostanoski*, K. McMahan*, C. Jacob-Dolan*, D. R. Martinez, A. Chang, et al., Immunogenicity of Ad26. COV2. S vaccine against SARS-CoV-2 variants in humans. Nature 596, 268-272 (2021). (* co-first author)

5、K. McMahan*, J. Yu*, N. B. Mercado*, C. Loos*, L. H. Tostanoski*, A. Chandrashekar*, J. Liu*, L. Peter, C. Atyeo, A. Zhu, et al., Correlates of protection against SARS-CoV-2 in rhesus macaques. Nature 590, 630-634 (2021). (* co-first author)

6、Yu, J., Thomas, P.V., McMahan, K., Jacob-Dolan, C., Liu, J., He, X., Hope, D., Martinez, E.J., Chen, W.H., Sciacca, M., et al. (2022). Protection against SARS-CoV-2 Omicron BA.1 variant challenge in macaques by prime-boost vaccination with Ad26.COV2.S and SpFN. Sci Adv 8, eade4433. 10.1126/sciadv.ade4433

7、Chandrashekar A*, Yu J*, McMahan K*, Jacob-Dolan C*, Liu J*, He X*, Hope D, Anioke T, Barrett J, Chung B, Hachmann NP, Lifton M, Miller J, Powers O, Sciacca M, Sellers D, Siamatu M, Surve N, VanWyk H, Wan H, Wu C, Pessaint L, Valentin D, Van Ry A, Muench J, Boursiquot M, Cook A, Velasco J, Teow E, Boon ACM, Suthar MS, Jain N, Martinot AJ, Lewis MG, Andersen H, Barouch DH. 2022. Vaccine protection against the SARS-CoV-2 Omicron variant in macaques. Cell 185:1549-1555 e11. (* co-first author)

获奖及个人荣誉：

1、美国俄亥俄州立大学杰出科研奖

2、哈佛大学华人生命科学杰出科研奖

联系方式：

Email: yu_jingyou@gzlab.ac.cn