主要研究呼吸道RNA病毒的感染致病机制以及抗病毒药物，主要聚焦冠状病毒。具体研究包括冠状病毒非结构蛋白的功能以及在病毒复制和致病中的作用，包括参与病毒RNA加工修饰的蛋白，研发靶向病毒聚合酶和甲基转移酶的抗病毒药物。

1、国家基金委重点基金（主持）：项目批准号：82230075，学校项目号：59000-41030049。项目名称：干细胞抗RNA病毒感染的关键因子与分子机制研究，直接费用：261.00万元，项目起止年月：2023.01-2027.12。

2、深圳市科技计划项目（主持）：技术攻关重点项目-项目名称：新冠肺炎（NCP）治疗的特异性药物研发；经费：800万元；执行期：2020.3 – 2022.12。

1、Liu Cao, Yingjun Li, Sidi Yang, …. Jincun Zhao, Xumu Zhang, Deyin Guo* (2022) The adenosine analog prodrug ATV006 is orally bioavailable and has preclinical efficacy against parental SARS-CoV-2 and variants. Science Translational Medicine 2022 May 17; 14 (661): eabm7621. doi: 10.1126/scitranslmed.abm7621.

2、Ruangang Pan, … Deyin Guo (2022) N7-methylation of the coronavirus RNA cap is required for maximal virulence by preventing innate immune recognition. mBio. 2022 Jan 25;13(1): e0366221. doi: 10.1128/mbio.03662-21.

3、Ping Li, Junyu Wu, … Deyin Guo (2022) The RNA polymerase of cytoplasmically replicating Zika virus binds with chromatin DNA in nuclei and regulates host gene transcription. Proceedings of the National Academy of Sciences of the United States of America 2022 Dec 6;119(49):e2205013119. doi: 10.1073/pnas.2205013119.

4、Jingshu Xiao, …, Deyin Guo (2022) CDK4/6 inhibition enhances oncolytic virus efficacy by potentiating tumor-selective cell killing and T cell activation in refractory glioblastoma. Cancer Research 2022 Jul 6: can.21.3656. doi: 10.1158/0008-5472.CAN-21-3656.

5、Panpan Hou… Deyin Guo* (2021) Autophagy receptor CCDC50 tunes STING-mediated interferon response in viral infection and autoimmune disease. Cellular & Molecular Immunology 2021 Oct;18(10):2358-2371. doi: 10.1038/s41423-021-00758-w.

6、Junyu Wu… Deyin Guo* (2021) Endogenous reverse transcriptase and RNase H-mediated antiviral mechanism in embryonic stem cells. Cell Research 2021 Sep;31(9):998-1010. doi: 10.1038/s41422-021-00524-7.

7、Fan Xing…, Deyin Guo (2021) Modulating the tumor microenvironment via oncolytic virus and PI3K inhibition synergistically restores immune checkpoint therapy response in PTEN-deficient glioblastoma. Signal transduction and Targeted Therapy 2021 Jul 28;6(1):275. doi: 10.1038/s41392-021-00609-0.

8、Panpan Hou…, and Deyin Guo* (2021) An unconventional role of an ASB family protein in NF-κB activation and inflammatory response during microbial infection and colitis. Proceedings of the National Academy of Sciences of the United States of America 2021 Jan 19;118(3):e2015416118. doi: 10.1073/pnas.2015416118.

9、Panpan Hou, … Deyin Guo* (2021) A novel selective autophagy receptor, CCDC50, delivers K63-polyubiquitination-activated RIG-I/MDA5 for degradation during viral infection. Cell Research 2021 Jan;3 1(1):62-79. doi: 10.1038/s41422-020-0362-1.