The SKLRD revealed the molecular mechanism of Plasmodium infection antagonizing tumor immunosuppressive microenvironment for the first time
2019-04-12985On April 12th, the international academic journal Cell Communication and Signaling published online the latest research results of the research team led by Chen Xiaoping of the laboratory on tumor immunotherapy, “Plasmodium infection inhibits the expansion and activation of MDSCs and Tregs in the tumor microenvironment in a murine Lewis lung cancer Model”. This research reveals for the first time that Plasmodium infection antagonizes the tumor immunosuppressive microenvironment and initially elucidates its molecular mechanism, which provides strong preclinical data support for Plasmodium for tumor immunotherapy. The study was conducted by Dickson Adah, a doctoral student at the laboratory, under the supervision of Dr. Chen Xiaoping and Dr. Qin Li. These findings have deepened the understanding of the anti-cancer mechanism of Plasmodium and provided further theoretical basis for the clinical study of Plasmodium immunotherapy for cancer.