1、m6A产生选择性修饰的机理及其意义

2、m6A选择性修饰和识别如何调控肺腺癌早期的发展

1、国家自然科学基金青年项目， YTHDF2通过其IDR结构域介导的液-液相分离选择性识别m6A位点的作用和机理，32300455，2024-01-01至2026-12-31，30万，主持

2、广东省区域联合基金-青年基金项目，线粒体RNA m6A修饰的鉴定与催化机理研究，2022A1515110255，2022-10-01至2025-09-30，10万，主持

3、高校基本科研业务费-中山大学青年教师培育项目，YTHDF2通过选择性识别m6A RNA修饰调控天然免疫的作用和机理，23ptpy66，2023-01至2023-12，10万，主持

4、国家自然科学基金面上项目，METTL3的乙酰化修饰特异性调控增强子RNA和启动子关联RNA的m6A修饰的作用和机理，2023-01-01至2026-12-31, 54万元，参与

1、Ren Z*,He J*, Huang X*, Gao Y*, Wei C*, Wu Z, Guo W, Wang F, Zhao Q, Sun X, Zhang J, Cao N, Lin L#, Wang J#, Cun Y#. Isoform characterization of m6A in single cells identifies its role in RNA surveillance, Nature Communications, 2025, 最后通讯

2、Huang X*, Zhang J*, Cun Y*, Ye M*, Ren Z*, Guo W,Ma X, Liu J, Luo W, Sun X, Shao J, Wu Z, Zhu X, Wang J#. Spatial control of m6A deposition on enhancer and promoter RNAs through co-acetylation of METTL3 and H3K27 on chromatin, Molecular Cell, 2025, 共一第三（Featured article, previewed by Chuan He）

3、Cun Y*, An S*, Zheng H*, Lan J, Chen W, Luo W, Yao C, Li X, Huang X, Sun X, Wu Z, Hu Y, Li Z, Zhang S, Wu G, Yang M, Tang M, Yu R, Liao X, Gao G, Zhao W, Wang J#, Li J#. Specific regulation of m6A by SRSF7 promotes the progression of glioblastoma, Genomics, Proteomics & Bioinformatics, 2023, 第一作者

4、Yu P*, Zhou S*, Gao Y, Liang Y, Guo W, Wang DO, Ding S, Lin S#, Wang J#, Cun Y#. Dynamic landscapes of tRNA transcriptomes and translatomes in diverse mouse tissues, Genomics, Proteomics & Bioinformatics, 2023, 最后通讯

5、Cun Y, Guo W, Ma B, Okuno Y, Wang J#. Decoding the specificity of m6A RNA methylation and its implication in cancer therapy, Molecular Therapy, 2024, 第一作者

6、Cun Y, Li J, Ye M, Huang X, Wang J#. Optimized GLORI-seq of chromatin-associated RNAs, Methods in Molecular Biology（Spring Nature出版社，经典实验方法指南丛书）, 2026, 受邀书籍章节，In press. 第一作者

7、Guo W*, Ren Z*, Huang X*, He J, Liu J, Shao J, Ma X, Wei C, Cun Y, He J, Zhang J, Wu Z, Guo Y, Zhang Z, Feng Z, He J, Wang J#. Single-molecule m6A detection empowered by endogenous labeling unveils complexities across RNA isoforms, Molecular Cell, 2025, 参与

8、Sun X*, Ren Z*, Cun Y, Zhao C, Huang X, Zhou J, Hu R, Su X, Ji L, Li P, Mak KLK, Gao F, Yang Y, Xu H, Ding J, Cao N, Li S, Zhang W, Lan P, Sun H, Wang J# and Yuan P#. Hippo-YAP signaling controls lineage differentiation of mouse embryonic stem cells through modulating the formation of super-enhancers, Nucleic Acids Research, 2020, 参与

9、An S*, Huang W*, Huang X*, Cun Y, Cheng W, Sun X, Ren Z, Chen Y, Chen W, Wang J#. Integrative network analysis identifies cell-specific trans regulators of m6A, Nucleic Acids Research, 2020, 参与

10、Zhao B*, Zhang W*, Cun Y, Li J, Liu Y, Gao J, Zhu H, Zhou H, Zhang R, Zheng P#. Mouse embryonic stem cells have increased capacity for replication fork restart driven by the specific Filia-Floped protein complex, Cell Research, 2018, 参与

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