从事人呼吸系统病毒性传染病致病机制与预防策略研究，聚焦呼吸道冠状病毒和流感病毒等重要呼吸道病原诱导的呼吸道黏膜适应性免疫应答作用及调控机制解析、呼吸道黏膜疫苗设计及疫苗免疫机理解析。

1、国家自然科学基金重大研究计划培育项目，92469101，上/下呼吸道冠状病毒特异性T细胞应答差异及作用机制研究，2025.01-2027.12，60万，主持

2、国家自然科学基金青年项目，82301996，呼吸系统冠状病毒交叉反应性T细胞识别图谱及作用机制研究，2024.01-2026.12，30万，主持

3、第八届全国“青年人才托举工程”（2022-2024），2022QNRC001，2022.10-2025.09，30万，主持

4、中国博士后科学基金，2022M720903，呼吸道中流感病毒特异性记忆性CD4+ T细胞来源和稳态维持机制研究，2023.01-2024.12，8万，主持

1、Zhen Zhuang#, Xiaomin Lai#, Jing Sun#, Zhao Chen#, …, Nanshan Zhong, Jingxian Zhao*, Dongsheng Zhou*, Jincun Zhao*. Mapping and Role of T Cell Response in SARS-CoV-2 infected Mice. J Exp Med (2021) 218 (4): e20202187.

2、Jing Sun#, Zhen Zhuang#, Jian Zheng#, Kun Li#, …, Paul B. McCray, Jr.*, Stanley Perlman*, Jincun Zhao*. Generation of a Broadly Useful Model for COVID-19 Pathogenesis, Vaccination, and Treatment. Cell. 2020, 182, 1–10.

3、Zhen Zhuang#, Jiaying Luo#, Guoxian Zhang#, Yifang He#, …, Jingxian Zhao*, Jing Sun*, Jincun Zhao*. Unveiling the Epitope Repertoires and Protective Roles of MERS-CoV-Specific T-Cells in Mice. Cell reports. Cell Rep. 2026 Feb 26;45(3):117043

4、Zhen Zhuang#, Donglan Liu#, Jing Sun#, Fang Li#, Jincun Zhao*. Immune responses to human respiratory coronaviruses infection in mouse models. Current Opinion in Virology. Volume 52, February 2022, Pages 102-111.

5、Zhen Zhuang#, Jianfen Zhuo#, …, Jincun Zhao*. Harnessing T-Cells for Enhanced Vaccine Development against Viral Infections. Vaccines. 2024 Apr 29;12(5):478. doi: 10.3390/vaccines12050478.

6、Yin-Feng Kang#, Cong Sun#, Zhen Zhuang#, Run-Yu Yuan#, …, Guo-Kai Feng*, Changwen Ke*, Jin-Cun Zhao*, Mu-Sheng Zeng*. Rapid Development of SARS-CoV-2 Spike Protein Receptor-Binding Domain Self-Assembled Nanoparticle Vaccine Candidates. ACS Nano. 2021 Feb 23;15(2):2738-2752.

7、Yaoxing Wu#, Ling Ma#, Zhen Zhuang#, Sihui Cai#, …, Jincun Zhao*, Jun Cui*. Main protease of SARS-CoV-2 serves as a bifunctional molecule in restricting type I interferon antiviral signaling. Signal Transduction and Targeted Therapy. 2020. 5:22

8、Yaoxing Wu#, Ling Ma#, Sihui Cai#, Zhen Zhuang#, …, Jincun Zhao* and Jun Cui*. RNA-induced liquid phase separation of SARS-CoV-2 nucleocapsid protein facilitates NF-κB hyper-activation and inflammation. Signal Transduction and Targeted Therapy 2021 Apr 24;6(1):167.

9、Jing Sun#, Airu Zhu#, Heying Li#, Kui Zheng#, Zhen Zhuang#, Zhao Chen#, …, Nanshan Zhong, Zifeng Yang*, Jicheng Huang*, Jincun Zhao*, Yi-min Li*. Isolation of infectious SARS-CoV-2 from urine of a COVID-19 patient. Emerging Microbes & Infections. 2020, VOL. 9.

10、Ming Liu#, Bingtai Lu#, Yue Li#, Shuofeng Yuan#, Zhen Zhuang#, Guangyu Li, …, Jincun Zhao*, Jasper Fuk-Woo Chan*, Yuxia Zhang*. P21-activated kinase 1 (PAK1)-mediated cytoskeleton rearrangement promotes SARS-CoV-2 entry and ACE2 autophagic degradation. Signal Transduction and Targeted Therapy (2023) 8:385