全体研究人员 学术带头人
名字:黄佳颖
职务:
职称:教授
研究方向:肺癌小结节早期干预及临床诊疗
联系方式:huangjy@gzhmu.edu.cn
研究工作

1、CRISPR精准编辑新方法的开发

2、通量化挖掘基因编辑新模块

3、基于CRISPR创制疾病模型与疾病治疗


科研项目

1、国家重点研发计划;“前沿生物技术”重点专项青年科学家项目,2024.12-2027.11,主持。

2、国家自然科学基金;青年科学基金项目,2025.1-2027.12,主持。

3、中国科协第十届青年人才托举工程项目,2025.1-2027.12,主持。

4、广州市科学技术局;2025年度基础与应用基础研究专题(科技菁英“领航”项目),2025.1-2027.12,主持。

5、2025年度广州市高校教学改革项目“新工科、新医科、新师范”建设项目;2025.9-2027.8,主持。

6、高校青年教师科研创新能力支持项目(U40项目),2026.1-2030.12,主持。

7、2025年广东省“特支”计划青年项目(教育厅平台)青年学者;2026.1-2028.12,主持。

8、江西省教育厅,2025年度江西省自然科学基金前沿技术项目,高效农作物基因编辑技术研究,2025.10-2028.10,参与。


代表性成果

1、Shi, Y.#, Yuan, Y.#, Qin, L.#, Zhou, F., Wu, G., Li, B., Yao, P., Shi, M., Ma, L., Wang, Y., Zhang, Y., Wang, C., Wang, X., Huang, B., Chen, J., Xiang, Z., Lin, Q.*, and Huang, J.* (2026). Optimizing linker length of base editors for precise crop breeding and gene therapy. Journal of Genetics and Genomics, S1673-8527(26)00065-2. Advance online publication.

2、Huang, J.#, Lin, Q.#, Fei, H.#, He, Z.#, Xu, H., Li, Y., Qu, K., Han, P., Gao, Q., Li, B., Liu, G., Zhang, L., Hu, J., Zhang, R., Zuo, E., Luo, Y., Ran, Y., Qiu, J.L., Zhao, K.T.*, and Gao, C.* (2023). Discovery of deaminase functions by structure-based protein clustering. Cell 186, 3182-3195. (F1000“杰出”评价,“Cell best of 2023”称号)

3、周方方,史远远,黄佳颖.碱基编辑系统开发及应用进展[J/OL].基因组学与应用生物学.2025

4、Huang, J.#, Dong, J.*, & Qu, L. J.* (2021). From birth to function: Male gametophyte development in flowering plants. Curr. Opin. Plant Biol. 63, 102118.

5、Valliyodan, B.#, Qiu, D.#, Patil, G.#, Zeng, P.#, Huang, J.#, Dai, L.#, Chen, C., Li, Y., Joshi, T., Song, L., Vuong, T. D., Musket, T. A., Xu, D., Shannon, J. G., Cheng, S., Liu, X.*, & Nguyen, H. T.* (2016). Landscape of genomic diversity and trait discovery in soybean. Sci. Rep. 6, 23598.

6、Shi, Y.#, Huang, J., Sun, T., Wang, X., Zhu, C., Ai, Y., and Gu, H.* (2017). The precise regulation of different COR genes by individual CBF transcription factors in Arabidopsis thaliana. J. Integr. Plant Biol. 59, 118–133.

7、Sun, Y.#, Huang, J., Zhong, S., Gu, H., He, S.*, and Qu, L.-J.* (2018). Novel DYW-type pentatricopeptide repeat (PPR) protein BLX controls mitochondrial RNA editing and splicing essential for early seed development of Arabidopsis. J. Genet. Genomics 45, 155–168.

8、Iorizzo, M.#, Ellison, S., Senalik, D., Zeng, P., Satapoomin, P., Huang, J., Bowman, M., Iovene, M., Sanseverino, W., Cavagnaro, P., Yildiz, M., Macko-Podgórni, A., Moranska, E., Grzebelus, E., Grzebelus, D., Ashrafi, H., Zheng, Z., Cheng, S., Spooner, D., Van Deynze, A., and Simon, P.* (2016). A high-quality carrot genome assembly provides new insights into carotenoid accumulation and asterid genome evolution. Nat. Genet. 48, 657-666.

9、Zhang, J.#, Huang, Q.#, Zhong, S.#, Bleckmann, A., Huang, J., Guo, X., Lin, Q., Gu, H., Dong, J., Dresselhaus, T., and Qu, L.-J.* (2017). Sperm cells are passive cargo of the pollen tube in plant fertilization. Nat. Plants 3, 17079.

10、Zhong, S.#, Liu, M.#, Wang, Z.#, Huang, Q., Hou, S., Xu, Y. C., Ge, Z., Song, Z., Huang, J., Qiu, X., Shi, Y., Xiao, J., Liu, P., Guo, Y. L., Dong, J., Dresselhaus, T., Gu, H., and Qu, L.-J.* (2019). Cysteine-rich peptides promote interspecific genetic isolation in Arabidopsis. Science 364, eaau9564.

11、Yuan, R.#, Lan, J., Fang, Y., Yu, H., Zhang, J., Huang, J., and Qin, G.* (2018). The Arabidopsis USL1 controls multiple aspects of development by affecting late endosome morphology. New Phytol. 219, 1388–1405.

12、Cheng, S.#, Gutmann, B.#, Zhong, X.#, Ye, Y., Fisher, M.F., Bai, F., Castleden, I., Song, Y., Song, B., Huang, J., Liu, X., Xu, X., Lim, B. L., Bond, C.S.*, Yiu, S.M.*, Small, I.* (2016). Redefining the structural motifs that determine RNA binding and RNA editing by pentatricopeptide repeat proteins in land plants. Plant J. 85, 532-547.


获奖及个人荣誉

1、广东省“特支”计划青年项目,入选第十届中国科协“青年人才托举工程”。