1、基于合成生物学、纳米生物学的新型疾病检测技术

2、基于微流控芯片与新型传感器件的生物传感系统

3、基于人工智能的生物大分子理性设计

1、国家重大科技项目-广州国家实验室专项项目，项目编号: GZNL2025A01008，重要呼吸道传播病原中和抗体战略储备，500万元，2025.11.30-2030.11.30，课题负责人；

2、国家重大科技项目-广州国家实验室专项项目，项目编号:GZNL2024A01007，污水传染性病原微生物监测技术，3000万元， 2024.01-2026.12，项目负责人；

3、国家重点研发计划（合成生物学专项），2024YFA0917703，代谢标志物高性能合成生物荧光传感系统，520万元，2024.12-2029.11，课题负责人；

4、国家重大科技项目-广州国家实验室专项项目，SRPG22-020，新冠及呼吸慢病检测核心关键技术研发，800万元，2022.07-2024.07，课题负责人；

5、国家重点研发计划（合成生物学专项），2019YFA0904801,面向生物过程检测的合成生物传感元器件设计与创建，2020.01-2024.12，177万，骨干；

6.、国家自然科学基金，面上项目，317710981003848，三特异性Janus纳米颗粒的胞内可控制备与多效应肿瘤免疫治疗，69.6万元，2018.01-2021.12，项目负责人；

7、国家自然科学基金，青年基金，模块化设计多功能蛋白纳米线及超灵敏生物传感应用，23万元，2013.01-2015.12，项目负责人。

1、Yingya Liu#, Jihang Zhai, Shanshan Cao, Huiying Guo, Hengwei Zhang, Bo Song, Jiajia Guo, Dong Men*, Xiao He*, Di Li*. Single-engineered-residue solvation perturbations regulate global protein architecture and function. Nat Commun 17, 3754 (2026).

2、Zheng Y, Zhang CY, Zhang Y, Zhou K, Tan PW, Liu YJ, Duan GT, Li HF, Chen CL, Guo CL, Li XD, Chen C, Ashaq Ali, Zhang Y*, Zhang XE*, Men D*. A Nanomaterial-Independent Biosensor Based on Gallium Arsenide High-Electron-Mobility Transistors for Rapid and Ultra-Sensitive Pathogen Detection. ACS Sens. 2025 Jun 27;10(6):3898-3908.

3、Zhou K, Zhou J, Cao S, Zheng Y, Zhang XY, Chen C, Zhang XE*, Men D*. Bifunctional Protein TC1 Mediated One-Pot Strategy for Robust Immobilization of DNA with High Accessibility. Small Methods. 2024 Dec;8(12):e2400049.

4、Feng XY, Gao D, Zhou J, Gui Z, Cai AL, Wang J, Dai J, Jing YP, Qian JC, Cui ZQ, Li LX, You Y, Tian LY, Zhang XE*, Dong Men D*. Viral capsid-mediated efficient cell labeling of micron-sized magnetic particles for highly sensitive long-term in vivo tumor cells MRI tracking. Chemical Engineering Journal. 2024 498(155830).

5、Lin Y, Yang M, Huang L, Yang F, Fan J, Qiang Y, Chang Y, Zhou W, Yan L, Xiong J, Ping J, Chen S, Men D*, Li F*. A bacteria-derived tetramerized protein ameliorates nonalcoholic steatohepatitis in mice via binding and relocating acetyl-coA carboxylase. Cell Rep. 2023 Nov 28;42(11):113453.

6、Chen C, Zhou J, Men D*, Zhang XE*. Promoter-regulated in vivo asymmetric self-assembly strategy to synthesize heterogeneous nanoparticles for signal amplification. Nanoscale. 2022 Nov 10;14(43):16180-16184.

7、Feng X#, Gao D#, Jing Y, Qian J, Cui Z, Zhou J, Zhang XE*, Men D*. Intracellular Delivery of Micron-Sized Magnetic Particles through a Virus Infection Pathway. ACS Appl Mater Interfaces. 2022 Oct 19;14(41):46850-46856.

8、Wei CH, Zhou J, Liu TG, Zhao WQ, Zhang XE*, Men D*. Self-Assembled Enzymatic Nanowires with a “Dry and Wet” Interface Improve the Catalytic Performance of Januvia Transaminase in Organic Solvents[J]. ACS Catalysis, 2021, 12: 372-382.

9、Jiang HW, Li Y, Zhang HN, Wang W, Yang X, Qi H, Li H, Men D*, Zhou J*, Tao SC*. SARS-CoV-2 proteome microarray for global profiling of COVID-19 specific IgG and IgM responses. Nat Commun. 2020 Jul 14;11(1):3581.

10、Li Y, Zhou J, Song J, Liang X, Zhang Z, Men D*, Wang D, Zhang XE*. Chemical nature of electrochemical activation of carbon electrodes. Biosens Bioelectron. 2019 Nov 1;144:111534.

11、Men D, Zhang TT, Hou LW, Zhou J, Zhang ZP, Shi YY, Zhang JL, Cui ZQ, Deng JY, Wang DB, Zhang XE*. Self-Assembly of Ferritin Nanoparticles into an Enzyme Nanocomposite with Tunable Size for Ultrasensitive Immunoassay. ACS Nano. 2015 Nov 24;9(11):10852-60.

12、Men D, Zhang ZP, Guo YC, Zhu DH, Bi LJ, Deng JY, Cui ZQ, Wei HP, Zhang XE. An auto-biotinylated bifunctional protein nanowire for ultra-sensitive molecular biosensing. Biosens Bioelectron. 2010 Dec 15;26(4):1137-41.

13、Men D, Guo YC, Zhang ZP, Wei HP, Zhou YF, Cui ZQ, Liang XS, Li K, Leng Y, You XY, Zhang XE. Seeding-induced self-assembling protein nanowires dramatically increase the sensitivity of immunoassays. Nano Lett. 2009 Jun;9(6):2246-50.

1、中科院“国科大”杯创新创业大赛二等奖（2019）

2、中科院青促会优秀会员（2018）

3、中科院“率先杯”未来技术创新大赛优胜奖（2018）

4、中科院青年创新促进会（2014）