科研项目
1、国家自然科学基金项目,PECAM-1通过Wnt/β-catenin信号通路介导肺血管内皮通透性改变在SARS-CoV-2相关ARDS中的作用及分子机制,2021/1- 2024/12 55万元,在研(主持)
2、广州市高新重大特色项目,支气管肺泡灌洗液宏基因组学测序联合PCR技术对COPD需要机械通气患者霉菌病的诊断价值, 2023/1- 2024/12 20万元,在研(主持)
3、广州医科大学学科建设项目,重症肺部感染和肺损伤机制研究,2023/1- 2025/12 19.2万元,在研(主持)
4、2017国家科技重大专项子课题项目,2017ZX10204401003,突发急性重症呼吸道传染病救治新技术和新方案研究,2017/08-2020/07,1113.23万元,已结题(主持)
5、2017广医高大建临床研究提升计划,巨细胞病毒活动性感染对机械通气的非免疫抑制患者肺部细菌及真菌感染性变化的研究,2017-2020,40万,已结题(主持)
代表性成果
1、Liu, X., Liu, X., Meng, J. Liu, X. et al. Electrical impedance tomography for titration of positive end-expiratory pressure in acute respiratory distress syndrome patients with chronic obstructive pulmonary disease. Crit Care 26, 339 (2022).
2、Liu X, Liu X, Xu Y, et al.Ventilatory Ratio in Hypercapnic Mechanically Ventilated Patients with COVID-19–associated Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med. 2020 May 15;201(10):1297-1299.
3、Huang Y, Chen S, Yang Z, et al. SARS-CoV-2 Viral Load in Clinical Samples from Critically Ill Patients. Am J Respir Crit Care Med. 2020 Jun 1;201(11):1435-1438.
4、Xu Z, Zhou J, Huang Y, et al.2020. Efficacy of convalescent plasma for the treatment of severe influenza. Crit Care 24:469.
5、Zhang R, Xu Y, Sang L, et al.Factors associated with intraoperative extracorporeal membrane oxygenation support during lung transplantation. Respiratory Research. 2020 Apr 15;21(1):85.
6、Zhang Z, Li Y, Liu X,et al.Cytomegalovirus reactivation in immunocompetent mechanical ventilation patients: a prospective observational study. BMC Infect Dis. 2021 Sep 30;21(1):1026.
7、Xu Y, Li M, Liu X, et al.Ribavirin Treatment for Critically Ill COVID-19 Patients: An Observational Study. Infect Drug Resist. 2021 Dec 10;14:5287-5291.
8、Zhang Z, Li R, Chen Y, et al. Association between active cytomegalovirus infection and lung fibroproliferation in adult patients with acute respiratory distress syndrome: a retrospective study. BMC Infect Dis. 2022 Oct 14;22(1):788.