呼吸道粘液纤毛清除系统损伤相关的呼吸疾病，包括慢性阻塞性肺疾病、呼吸道病毒感染、原发性纤毛不动症、支气管扩张、哮喘等，聚焦：

1、粘液纤毛清除系统损伤的早期诊断；

2、粘液纤毛清除系统的损伤机制；

3、恢复/增强粘液纤毛清除功能的药物研发；

1、“四大慢病”国家科技重大专项，慢阻肺病全病程演变规律和关键分子表型研究，2024-2028，主持

2、国家重点研发计划干细胞研究与器官修复专项-气道基底层干细胞移植治疗呼吸系统重大疾病确证性临床研究 ，2024-2027，骨干

3、国自然优秀青年科学基金，粘液纤毛清除与慢性阻塞性肺疾病，2023-2025，主持

4、国自然面上项目，微管谷氨酸化在气道粘液纤毛清除系统维持和损伤中的功能和机制研究，2023-2026，主持

5、广州实验室专项，遗传因素在慢性阻塞性肺疾病演进中的作用，2023-2028，主持

6、广州实验室专项，慢阻肺早期演进的代谢调控机制与干预策略研究，2023-2028，骨干

7、国家重大人才工程入选专家广东省配套补助资金，2024

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2、Peng Y, Chen S, Wang Z, Zhou Z, Sun J, Zhang G, Li J, Wang L, Zhao J, Tang X, Wang D, Zhong N. (2023). Dicoumarol is an effective post-exposure prophylactic for SARS-CoV-2 Omicron infection in human airway epithelium. Signal Transduct Target Ther. PMID: 37301869.

3、Wang, L.*, Paudyal, S., Kang, Y., Owa, M., Liang, F., Spektor, A. Knaut, H., Sánchez, I., and Dynlacht, B. D*. (2022). Regulators of tubulin poly-glutamylation control nuclear shape and cilium disassembly by balancing microtubule and actin assembly. Cell Research. PMID: 34782749.（*共同通讯作者）

4、Wang, L., Failler, M., Fu, W., and Dynlacht, B. D*. (2018). A distal centriolar protein network controls organelle maturation and asymmetry. Nature Communications. PMID: 30258116.

5、Wang, L.*, and Dynlacht, B. D. *(2018). The regulation of cilium assembly and disassembly in development and disease. Development. PMID: 30224385.（*共同通讯作者）

6、Wang, L.#, Lee, K.#, Malonis, R., Sanchez, I., and Dynlacht, B. D*. (2016). Tethering of an E3 ligase by PCM1 regulates the abundance of centrosomal KIAA0586/Talpid3 and promotes ciliogenesis. eLife. PMID: 27146717.

7、Fu, W., Wang, L., Kim, S., Li, J., and Dynlacht, B. D. (2016). Role for the IFT-A complex in selective transport to the primary cilium. Cell Reports. PMID: 27806291.

8、Wang, L#., Fu, C.#, Fan, H., Du, T., Dong, M., Chen, Y., Jin, Y., Zhou, Y., Deng, M., Gu, A*., Jing Q. *, Liu T.*, and Zhou Y*. (2013). miR-34b regulates multiciliogenesis during organ formation in zebrafish. Development. PMID: 23698347.

9、Wang, L.#, Zhang, Y.#, Zhou, T., Fu, Y. F., Du, T. T., Jin, Y., Chen, Y., Ren, C. G., Peng, X. L., Deng, M., and Liu, T*. (2008). Functional characterization of lmo2-Cre transgenic zebrafish. Developmental dynamics. PMID: 18627109.

1、DOD Prostate Cancer Research Program, Postdoctoral Training Award, USA, 2016-2018