导师介绍
| 姓名 | 晏杰 | 性别 | 男 |
| 民族 | 汉族 | 导师层次 | 硕士生导师 |
| 职称 | 教授 | 导师类型 | 学术型 |
| 学历 | 博士 | 学位 | 博士 |
| 行政职务 | 无 | 邮箱 | jieyan@gzhmu.edu.cn |
| 招生方向 | 免疫学 | ||
2003年本科毕业于北京大学医学部基础医学专业；2003-2006年就读于北京协和医学院生物医学工程研究所，获得硕士学位；2006-2009年就读于北京协和医学院肿瘤医院肿瘤研究所，获得博士学位。2009年9月，赴美国芝加哥大学Ben May Department for Cancer Research，从事博士后以及助理研究员的工作。2017年初，通过高水平大学建设项目引进回国，就职于广州医科大学附属第二医院过敏反应科教授。同时，担任过敏反应研究领域多项学术任职，包括中华医学会变态反应分会青年委员，广东省预防医学会过敏病预防与控制专业委员会常务委员，广东省医学会变态反应学会专业委员会委员。
研究方向为细胞程序性死亡及炎症的分子调控机制。长期从事过敏、肠炎、哮喘等炎症以及过敏相关疾病的发病机理以及细胞信号转导网络分子机制研究的工作，特别是细胞程序性死亡调控分子机制，首次提出细胞毒性TNFα调控细胞凋亡的分子通路，并且对相关调控分子的抑制剂应用于败血症的临床治疗做了初步的探索。目前的研究工作主要从炎症的疾病耐受角度对过敏性疾病临床治疗提供新的策略，深入挖掘其分子调控机制和应用于临床治疗的可行性，为有序的临床实验提供有价值的科学依据。
1、Qile Chen, Yuyi Huang, Junjie Wen, Canyang Liang, Yuhuan Wen, Jing Wang, Suda Gu, Honglv Chen, Sijie Wu, Enli Zhang, Bowen Sun, Qingling Zhang*, Jie Yan*. 2026. FOXA1-mediated CEPT1 deficiency in airway epithelium drives asthma via an ER stress-mitochondrial dysfunction axis. Cell Reports, 2026 45(6): 117368. IF=6.9
2、Yujiao Chen, Min Chen, Huifang Chen, Jin-Hong Zhu, Canyang Liang, Sijie Wu, Suda Gu, Weimin Sun*, Jie Yan*. 2025. Crosstalk patterns of necroptosis signaling and NLRP3 inflammasome in the colonic epithelium and its initial role in colitis. International Immunopharmacology, 2025, 152, 114413. IF=4.7
3、Guan, J., Yao, W., Zhang, L., Xie, H., Li, L., Wen, Y., Chen, H., Huang, Y., Wen, J., Ou, C., Liang, C., Wang, J., Zhang, Q*., Tao, A*., Yan, J*. 2024. Contribution of Pseudomonas aeruginosa mediated club cell necroptosis to the bias of type 17 inflammation and steroid insensitivity in asthma. Journal of Advanced Research, 2025, 75:137-149. IF=11.4
4、Wen, Y., Chen, Q., Wang, H., Xie, S., Chen, H., Yao, W., Zhang, L., Sun, W., Wen, J., Yang, X., Chung, KF., Zhang, Q*., Tao, A*., Yan, J*. Contribution of IL-17C-mediated macrophage polarization to Type 17 inflammation in neutrophilic asthma. Cell Communication and Signaling, 2024, 22: 557. IF=8.4
5、Li, H., Guan, J., Chen, J., Sun, W., Chen, H., Wen, Y., Chen, Q., Xie, S., Zhang, X., Tao, A*., Yan, J*. 2022. Necroptosis signaling and NLRP3 inflammasome cross-talking in epithelium facilitate Pseudomonas aeruginosa mediated lung injury. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2023, 1869(3): 166613. IF=6.633
6、Wang, H., Wen, Y., Wang, L., Wang, J., Chen, H., Chen, J., Guan, J., Xie, S., Chen, Q., Wang, Y., Tao, A*., Du, Y*., Yan, J*. 2022. DDR1 activation in macrophage promotes IPF by regulating NLRP3 inflammasome and macrophage reaction. International Immunopharmacology, 2022, 113(2022): 109294. IF=5.6
7、He, A., Chen, J., Guan, J., Huang, Y., Xie, H., Chen, H., Wen, Y., Chen, Q., Xie, S., Li, H., Ou, C., Zhang, Q*., Tao, A*., Yan, J*. 2022. Selective eosinophil necroptosis contributes to airway inflammation and remodeling in asthma. Allergy. 77(11): 3456-3459. IF=14.710
8、Zhang, C., Chen, H., He, Q., Luo, Y., He, A., Tao, A*., Yan, J*. 2021. Fibrinogen/AKT/microfilament axis promotes colitis by enhancing vascular permeability. Cellular and Molecular Gastroenterology and Hepatology. 11(3): 683-696. IF=8.797
9、Chen, H., He, A., Li, H., Chen, H., Xie, H., Luo, L., Huang, Y., Chen, J., Guang, J., He, Q., Ma, J., Ou, C., Tao, A*., Yan, J*. 2021. TSSK4 upregulation in alveolar epithelial type-II cells facilitates pulmonary fibrosis through HSP90-AKT signaling restriction and AT-II apoptosis. Cell death & disease. 12(10): 938-952. IF=9.685
10、Yang, W., Li, Y., Liu, S., Sun, W., Huang, H., Zhang, Q*., Yan, J*. 2021. Inhibition of ULK1 promotes the death of leukemia cell in an autophagy irrelevant manner and exerts the anti-leukemia effect. Clinical and Translational Medicine. 11(1): e282-287. IF=8.554
11、Yang, W., Liu, S., Li, Y., Wang Y., Deng, Y., Sun, W., Huang, H., Xie, J., He, A., Chen, H., Tao, A*., Yan, J*. 2020. Pyridoxine induces monocyte-macrophages death as specific treatment of acute myeloid leukemia. Cancer Letters. 492: 96-105. IF=9.756
12、Zhang, C., He, A., Liu, S., He, Q., Luo, Y., He, Z., Chen, Y., Tao, A*., Yan, J*. 2019. Inhibition of HtrA2 alleviated dextran sulfate sodium (DSS)-induced colitis by preventing necroptosis of intestinal epithelial cells. Cell death & disease. 2019, 10(5): 344-358. IF = 9.685
13、Zhang, C., Luo, Y., He, Q., Liu, S., He, A., Jie Yan*. 2019. A pan-RAF inhibitor LY3009120 inhibits necroptosis by preventing phosphorylation of RIPK1 and alleviates dextran sulfate sodium (DSS)-induced colitis. Clinical Science. 2019, 133(8):919-932. IF = 6.876
14、Yan, J., Zhang, H., Xiang, J., Zhao, Y., Sun, B., Lin, A*. 2018. The BH3-only protein BAD mediates TNFα cytotoxicity despite concurrent activation of IKK and NF-kb in septic shock. Cell Research. 28(7): 701-718. IF = 46.297
15、Yan, J., Xiang, J., Lin, Y., Ma, J., Zhang, J., Zhang, H., Sun, J., Danial, NN., Liu, J., Lin, A*. 2013. Inactivation of BAD by IKK inhibits TNFa-induced apoptosis independently of NF-Kb activation. Cell. 152(1-2): 304-315. IF= 66.85
16、Yan, J., Jin, S., Zhan, Q*. 2010. Aurora B interaction of centrosomal Nlp regulates cytokinesis. Journal of Biological Chemistry. 285 (51): 40230-40239. IF=5.486
